5-乙基吲哚-3-乙酸 | 52531-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-乙基吲哚-3-乙酸
• 英文名称: 2-(5-ethyl-1H-indol-3-yl)acetic acid
• CAS: 52531-12-1
• 化学式: C₁₂H₁₃NO₂
• mdl: MFCD00127887
• 分子量: 203.24
• InChiKey: ZWXOHBRBIAQHFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

文献信息

• DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS
  申请人：Pinto Donald J.P.

  公开号：US20100173899A1

  公开（公告）日：2010-07-08

  Disclosed are novel dipeptide analogs compounds of Formula (I), (II) or (III): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, which are inhibitors of factor XIa and/or plasma kallikrein, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of thrombotic diseases.

  本发明涉及化合物的新型二肽类似物，其化学式为(I)、(II)或(III)：或其立体异构体、互变异构体、药学上可接受的盐、溶剂化物或前药，其为血凝酶因子XIa和/或血浆卡利肌酶的抑制剂，含有它们的组合物以及使用它们的方法，例如用于治疗或预防血栓性疾病。
• PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3438108A1

  公开（公告）日：2019-02-06

  The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.

  本发明涉及由式（I）代表的苯基[a]吲哚[2,3-g]喹嗪化合物、其制备方法、药物组合物及其应用。具体应用是制备治疗与丙蛋白转化酶亚基克毒素-9（PCSK9）相关疾病的药物的应用，包括制备治疗高脂血症、高胆固醇血症、高甘油三酯血症、脂肪肝变形、动脉粥样硬化、肥胖和其他代谢性疾病的药物的应用。
• Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：US10927107B2

  公开（公告）日：2021-02-23

  The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.

  本发明涉及由式（I）代表的苯基[a]吲哚[2,3-g]喹嗪化合物、其制备方法、药物组合物及其应用。具体应用是制备治疗与丙蛋白转化酶亚基克毒素-9（PCSK9）相关疾病的药物的应用，包括制备治疗高脂血症、高胆固醇血症、高甘油三酯血症、脂肪肝变形、动脉粥样硬化、肥胖和其他代谢性疾病的药物的应用。
• Auxinic analogues of indole-3-acetic acid
  申请人：Life Technologies, Inc.

  公开号：US20030087762A1

  公开（公告）日：2003-05-08

  The present invention provides compounds and compositions capable of stimulating plant growth, regeneration of plant cells and tissues, and transformation of plant cells and tissues, comprising mono- and multi-substituted auxinic analogues of indole-3-acetic acid (IAA) comprising substituent groups such as halo-, alkyl-, alkoxy-, acyl-, acylamido- and acyloxy-groups. The invention relates to a method of using such mono- and multi-substituted auxinic analogues of IAA to affect growth, regeneration or transformation in monocotyledonous and dicotyledonous plants, as well as in transgenic plant tissues. The invention also contemplates the use of these auxinic IAA analogues in the presence of other plant growth regulators, such as cytokinin, etc., to enhance plant growth.

  本发明提供了能够刺激植物生长、植物细胞和组织再生以及植物细胞和组织转化的化合物和组合物，其包含吲哚-3-乙酸(IAA)的单取代和多取代的辅助类似物，该类似物包含取代基团，例如卤基、烷基、烷氧基、酰基、酰氨基和酰氧基。本发明涉及一种使用 IAA 的这种单取代和多取代助剂类似物来影响单子叶和双子叶植物以及转基因植物组织的生长、再生或转化的方法。本发明还考虑在存在其他植物生长调节剂（如细胞分裂素等）的情况下使用这些辅助性 IAA 类似物来促进植物生长。
• AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID
  申请人：LIFE TECHNOLOGIES, INC.

  公开号：EP0866850A1

  公开（公告）日：1998-09-30