(5R)-12-methyl-4-[(1R)-1-phenylethyl]-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraen-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5R)-12-methyl-4-[(1R)-1-phenylethyl]-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraen-3-one
• 化学式: C₂₃H₂₄N₂O
• 分子量: 344.4
• InChiKey: SVWIFMOPOCWQOQ-IIBYNOLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PROCESS FOR THE PREPARATION OF PIPERAZINE RING FOR THE SYNTHESIS OF PYRAZINOCARBAZOLE DERIVATIVES
  申请人：TECNIMEDE-SOCIEDADE TECNICO-MEDICINAL, S.A.

  公开号：EP3392250A1

  公开（公告）日：2018-10-24

  The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salts thereof.

  本公开涉及一种改进的哌嗪环合成工艺，特别是用于制备吡嗪咔唑（如抗抑郁药 Pirlindole）合成中间体的杂环化合物。 所述工艺可用于制备 Pirlindole 对映体或其药用盐。
• Processes for the preparation of pharmaceutically acceptable salts of (R)-Pirlindole and (S)-Pirlindole
  申请人：TECNIMEDE, SOCIEDADE TÉCNICO-MEDICINAL, SA

  公开号：US11008327B2

  公开（公告）日：2021-05-18

  The present disclosure relates to an improved process for the synthesis of piperazine ring, particularly for the preparation of heterocyclic compounds useful as intermediates in the synthesis of pyrazinocarbazoles such as the antidepressant Pirlindole. The process described is useful to prepare Pirlindole enantiomers, or a pharmaceutically accepted salt thereof.

  本公开涉及一种改进的哌嗪环合成工艺，特别是用于制备吡嗪咔唑（如抗抑郁药 Pirlindole）合成中间体的杂环化合物。所述工艺可用于制备 Pirlindole 对映体或其药用盐。