Synthesis of derivatives of 3-acetyl-2-aminopyrrole and pyrolo[2,3-d]pyrimidine from monoacetylketene aminals
作者:A. V. Komkov、V. S. Bogdanov、V. A. Dorokhov
DOI:10.1007/bf01431814
日期:1996.7
A new scheme for the synthesis of pyrrolo[2,3-d]pyrimidinesfrom monoacetylketene animals was proposed. Reactions of monoacetylketeneN-benzoyl- andN-acetylaminals with α-bromoacetophenone afforded the corresponding 3-acetyl-2-acylamino-5-phenyl- lH-pyr-roles, which underwent cyclization to 2,4,6-trisubstituted 7Hl-pyrrolo[2,3-d]pyrimidines under the action of ammonium acetate in boiling BuOH.