(11Z,14E,17E)-eicosa-11,14,17-trienoic acid | 2091-27-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (11Z,14E,17E)-eicosa-11,14,17-trienoic acid
• 英文别名: Z-11,14,17-eicosatrienoic acid；(11Z,14E,17E)-icosa-11,14,17-trienoic acid
• CAS: 2091-27-2
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.489
• InChiKey: AHANXAKGNAKFSK-KYNNUBNZSA-N

物化性质

• 沸点：
  432.7±14.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMPOSITIONS AND METHODS OF DELIVERY OF DEUBIQUITINASE INHIBITORS<br/>[FR] COMPOSITIONS ET MÉTHODES D'ADMINISTRATION D'INHIBITEURS DE DÉUBIQUITINASE
  申请人：PHARMAKEA INC

  公开号：WO2015183987A1

  公开（公告）日：2015-12-03

  Described herein are compositions comprising deubiquitinase inhibitors in combination with albumin, methods of making such compositions, and methods of using such compositions in the treatment of conditions, diseases, or disorders that would benefit from inhibition of deubiquitinase activity.

  本文描述了含有去泛素化酶抑制剂与白蛋白组合的组合物，制备这种组合物的方法，以及利用这种组合物治疗需要抑制去泛素化酶活性的病症、疾病或紊乱的方法。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• [EN] COMPOSITIONS COMPRISING AN UROLITHIN COMPOUND<br/>[FR] COMPOSITIONS COMPRENANT UN COMPOSÉ UROLITHINE
  申请人：AMAZENTIS SA

  公开号：WO2017036993A1

  公开（公告）日：2017-03-09

  The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

  本发明提供了包含蛋白质来源和尿石素的组合物。本发明还提供了与该组合物相关的用途和方法，例如药物、膳食补充剂、功能性食品或医疗食品，以及在治疗和/或预防肌肉相关病理状况方面的用途。本发明还提供了包含尿石素和蛋白质的试剂盒。
• [EN] COMPOSITIONS COMPRISING UROLITHIN COMPOUNDS<br/>[FR] COMPOSITIONS COMPRENANT DES COMPOSÉS D'UROLITHINE
  申请人：AMAZENTIS SA

  公开号：WO2017036992A1

  公开（公告）日：2017-03-09

  The invention provides compositions comprising a medium chain triglyceride and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions,such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition.

  本发明提供了包含中链甘油三酯和尿石素的组合物。本发明还提供了与该组合物相关的用途和方法，例如药物、膳食补充剂、功能性食品或医疗食品，以及治疗和/或预防与肌肉相关的病理性状的方法。
• METHOD FOR IMPROVING MITOPHAGY IN SUBJECTS
  申请人：Amazentis SA

  公开号：US20180256539A1

  公开（公告）日：2018-09-13

  The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prophylaxis of a condition, disease or disorder in a subject, wherein the compound or salt is orally administered to a subject in a daily amount of from 2.8 to 6.6 mmol per day, over a period of at least 21 days. Also are provided are the compound of formula (I) for use in increasing mitophagy and/or autophagy, maintaining and/or improving muscle function and administration as a dietary, nutritional and/or health supplement.

  本发明提供了化合物(I)的公式，其中A、B、C、D、W、X、Y和Z各自独立地选择H和OH；或其盐；用于治疗和/或预防受试者的状况、疾病或障碍，其中该化合物或盐以每天2.8至6.6毫摩尔的剂量口服给予受试者，持续至少21天。此外，还提供了公式(I)的化合物，用于增加线粒体自噬和/或自噬作用，维持和/或改善肌肉功能，并作为膳食、营养和/或健康补充剂给予。