(3-methyloxetan-3-yl)methyl trifluoromethanesulfonate | 1140964-92-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (3-methyloxetan-3-yl)methyl trifluoromethanesulfonate
• 英文别名: (3-Methyloxetan-3-yl)methyl trifluoromethanesulfonate
• CAS: 1140964-92-6
• 化学式: C₆H₉F₃O₄S
• 分子量: 234.196
• InChiKey: GBRTYIPTASPVQA-UHFFFAOYSA-N

物化性质

• 沸点：
  215.8±35.0 °C(Predicted)
• 密度：
  1.447±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-甲基-3-羟甲基氧杂环丁烷 、 三氟甲磺酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (3-methyloxetan-3-yl)methyl trifluoromethanesulfonate
  参考文献：
  名称：

  [EN] EP1 RECEPTOR LIGANDS
  [FR] LIGANDS DU RÉCEPTEUR EP1

  摘要：

  本发明属于EP1受体配体领域。更具体地，它涉及具有对EP1受体具有很高亲和力和选择性的一般式(I)化合物。该发明还涉及它们的制备方法，以及它们作为治疗和/或预防由EP1受体介导的疾病或紊乱的药物的用途，以及包含它们的药物组合物。

  公开号：

  WO2013037960A1

文献信息

• Process for the manufacture of polyol perfluoropolyether derivative
  申请人：Tonelli Claudio

  公开号：US20100240930A1

  公开（公告）日：2010-09-23

  A process for the manufacture of a polyol (per)fluoropolyether derivative, comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group with an activating agent, to yield an activated protected triol; 2. reacting the activated protected triol with a functional (per)fluoropolyether derivative of formula: T 2 -O—R f -T 1 , wherein: R f represents a fluoropolyoxyalkene chain which is a fluorocarbon segment comprising ether linkages in main chain; T 1 and T 2 , equal to or different from each other, are independently selected from non-functional groups of formula: —CF 3 , —CF 2 —CF 3 , —CF 2 Cl, —CF 2 CF 2 Cl, —CF 2 —COF, —COF: and functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T 1 and T 2 is a functional hydroxyl group as above detailed to yield a protected polyol (per)fluoropolyether derivative; and 3. deprotecting the protected polyol (per)fluoropolyether derivative to yield the polyol (per)fluoropolyether derivative.

  一种用于制造聚醚（全氟）聚醚醚衍生物的工艺，包括：1. 将至少一种具有两个受保护的羟基功能和一个自由羟基的三醇与活化剂反应，以产生活化的受保护三醇；2. 将活化的受保护三醇与具有以下结构的功能性（全氟）聚醚醚衍生物反应：T2-O—Rf-T1，其中：Rf代表氟聚氧烷链，是一种含有主链中醚键的氟碳段；T1和T2，可以相等也可以不同，独立地选择自以下结构的非功能性基团：—CF3，—CF2—CF3，—CF2Cl，—CF2CF2Cl，—CF2—COF，—COF：和包含至少一个羟基的功能性羟基基团，但至少其中一个为上述详细的功能性羟基基团，以产生受保护的聚醚（全氟）聚醚醚衍生物；3. 脱保护受保护的聚醚（全氟）聚醚醚衍生物，以产生聚醚（全氟）聚醚醚衍生物。
• EP1 RECEPTOR LIGANDS
  申请人：Torrens Jover Antoni

  公开号：US20140323475A1

  公开（公告）日：2014-10-30

  The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.

  本发明属于EP1受体配体领域，更具体地，它指的是具有EP1受体亲和力和选择性的一般式(I)化合物。该发明还涉及它们的制备过程，它们作为治疗和/或预防由EP1受体介导的疾病或疾病的药物的使用，以及包含它们的制药组合物。
• PROCESS FOR THE MANUFACTURE OF POLYOL PERFLUOROPOLYETHER DERIVATIVE
  申请人：Solvay Specialty Polymers Italy S.p.A.

  公开号：EP2197939B1

  公开（公告）日：2012-07-11
• US9518015B2
  申请人：——

  公开号：US9518015B2

  公开（公告）日：2016-12-13
• [EN] PROCESS FOR THE MANUFACTURE OF POLYOL PERFLUOROPOLYETHER DERIVATIVE<br/>[FR] PROCÉDÉ DE FABRICATION D'UN DÉRIVÉ DE POLYOL ET DE PERFLUOROPOLYÉTHER
  申请人：SOLVAY SOLEXIS SPA

  公开号：WO2009043928A1

  公开（公告）日：2009-04-09

  The invention pertains to a process for the manufacture of a polyol (per)fluoropolyether derivative [polyol PFPE (PFPE-OH)], said process comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group [protected triol (PT)] with an activating agent, to yield an activated protected triol [activated protected triol (APT)]; 2. reacting said activated protected triol with a functional (per)fluoropolyether derivative of formula (Ia) [functional PFPE (E)], wherein: Rf represents a fluoropolyoxyalkene chain (chain Rf), i.e. a fluorocarbon segment comprising ether linkages in main chain; T1 and T2, equal to or different from each other, are independently selected from - non-functional groups of formula: -CF3, -CF2-CF3, -CF2CI, -CF2CF2CI, -CF2-COF, -COF : and - functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T1 and T2 is a functional hydroxyl group as above detailed; to yield a protected polyol (per)fluoropolyether derivative [protected polyol PFPE (p-PFPE-OH)]; 3. deprotecting said protected polyol PFPE (p-PFPE-OH) to yield the polyol PFPE (PFPE-OH).