6-ethyl-2-phenyl-3H-imidazo[4,5-f]quinolin-7(6H)-one | 1520081-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 6-ethyl-2-phenyl-3H-imidazo[4,5-f]quinolin-7(6H)-one
• 英文别名: 6-ethyl-2-phenyl-3H-imidazo[4,5-f]quinolin-7-one
• CAS: 1520081-91-7
• 化学式: C₁₈H₁₅N₃O
• 分子量: 289.337
• InChiKey: RRUXTJJUWPNYBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-amino-5-bromo-1-ethylquinolin-2(1H)-one 、 苯甲醛 在 indium(III) chloride 、 sodium azide 作用下， 以 二甲基亚砜 为溶剂， 反应 8.0h， 以77%的产率得到6-ethyl-2-phenyl-3H-imidazo[4,5-f]quinolin-7(6H)-one
  参考文献：
  名称：

  Indium(III) Chloride Catalyzed One-Pot Multicomponent Synthesis of Chromenone- and Quinolone-Annulated Imidazole Derivatives

  摘要：

  A one-pot multicomponent strategy for the synthesis of chromenone- and quinolone-annulated imidazole derivatives from easily available starting materials has been achieved via an indium(III) chloride catalyzed domino reaction. The protocol is simple, step-economic, and less hazardous, and also provides good yields of the products.

  DOI：

  10.1055/s-0033-1339547

文献信息

• Indium(III) Chloride Catalyzed One-Pot Multicomponent Synthesis of Chromenone- and Quinolone-Annulated Imidazole Derivatives
  作者：K. Majumdar、Debankan Ghosh、Sudipta Ponra

  DOI：10.1055/s-0033-1339547

  日期：——

  A one-pot multicomponent strategy for the synthesis of chromenone- and quinolone-annulated imidazole derivatives from easily available starting materials has been achieved via an indium(III) chloride catalyzed domino reaction. The protocol is simple, step-economic, and less hazardous, and also provides good yields of the products.