(E)-7-bromo-2-heptenoic acid | 10221-54-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-7-bromo-2-heptenoic acid
• 英文别名: trans-7-Brom-2-heptensaeure；7-Bromhept-2-ensaeure；(e)-7-Bromo-2-heptenic acid；(E)-7-bromohept-2-enoic acid
• CAS: 10221-54-2
• 化学式: C₇H₁₁BrO₂
• 分子量: 207.067
• InChiKey: MJIAWEWWXRURBS-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-7-bromo-2-heptenoic acid 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以77%的产率得到(E,E)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
  参考文献：
  名称：

  Maciejewski, Lucien; Martin, Marius; Ricart, Gui, Synthetic Communications, 1988, vol. 18, # 15, p. 1757 - 1762

  摘要：

  DOI：
• 作为产物：
  描述：

  四氢-2H-吡喃-2-乙酸 生成 (E)-7-bromo-2-heptenoic acid
  参考文献：
  名称：

  739.皇后物质的新合成

  摘要：

  DOI：

  10.1039/jr9610003813

文献信息

• Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties
  申请人：——

  公开号：US20020016294A1

  公开（公告）日：2002-02-07

  The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.

  本发明披露了新型大环化合物，具有HCV蛋白酶抑制活性，以及制备这种化合物的方法。在另一实施例中，本发明披露了包含这种大环化合物的药物组合物，以及使用它们治疗与HCV蛋白酶相关的疾病的方法。
• Phenolic thioethers, their production and use
  申请人：SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

  公开号：EP0348203B1

  公开（公告）日：1993-02-24
• MACIEJEWSKI, LUCIEN;MARTIN, MARIUS;RICART, GUY;BROCARD, JACQUES, SYNTH. COMMUN., 18,(1988) N 5, C. 1757-1762
  作者：MACIEJEWSKI, LUCIEN、MARTIN, MARIUS、RICART, GUY、BROCARD, JACQUES

  DOI：——

  日期：——
• MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING ALKYL AND ARYL ALANINE P2 MOIETIES
  申请人：SCHERING CORPORATION

  公开号：EP1274724A2

  公开（公告）日：2003-01-15
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.