2-allyl-2-ethyl-4-pentenoyl chloride | 159225-73-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2-allyl-2-ethyl-4-pentenoyl chloride
• 英文别名: 2-ethyl-2-prop-2-enylpent-4-enoyl chloride
• CAS: 159225-73-7
• 化学式: C₁₀H₁₅ClO
• 分子量: 186.681
• InChiKey: ACXUBHFMTVBVLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-allyl-2-ethyl-4-pentenoyl chloride 在 iodonium(di-γ-collidine) perchlorate 、 sodium 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 48.0h， 生成 (S)-3-Allyl-3-ethyl-5-iodomethyl-dihydro-furan-2-one
  参考文献：
  名称：

  Highly enantioselective creation of quaternary carbons in a halolactonization of bis-γ,δ-unsaturated carboxylic imides derived from a camphorsultam: Enantioselective synthesis of (+)-mesembrine

  摘要：

  Iodolactonization of symmetrical diene-carboxylic imides (3a,b), derived from a camphorsultam, afforded chiral lactones (5) and (6) possessing aromatic substituents on quaternary carbons in high enantioselectivity with moderate diastereoselectivity.

  DOI：

  10.1016/s0040-4039(00)60916-4
• 作为产物：
  描述：

  2-ethyl-2-allyl-4-pentenoic acid 在 氯化亚砜 作用下， 生成 2-allyl-2-ethyl-4-pentenoyl chloride
  参考文献：
  名称：

  Highly enantioselective creation of quaternary carbons in a halolactonization of bis-γ,δ-unsaturated carboxylic imides derived from a camphorsultam: Enantioselective synthesis of (+)-mesembrine

  摘要：

  Iodolactonization of symmetrical diene-carboxylic imides (3a,b), derived from a camphorsultam, afforded chiral lactones (5) and (6) possessing aromatic substituents on quaternary carbons in high enantioselectivity with moderate diastereoselectivity.

  DOI：

  10.1016/s0040-4039(00)60916-4

文献信息

• Hexahydronaphthalene ester derivatives, their preparation and their
  申请人：Sankyo Company, Limited

  公开号：US05451688A1

  公开（公告）日：1995-09-19

  Compounds of formula (I): ##STR1## [wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is hydrogen or a group of formula and --OR.sup.6 ; R.sup.6, R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arylsulfonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

  化合物的化学式（I）：##STR1## [其中R.sup.1代表化学式（II）或（III）的基团：##STR2## R.sup.2是烷基，烯基或炔基；R.sup.3和R.sup.4分别是氢，烷基，烯基或炔基；R.sup.5是氢或羧基保护基团；R.sup.a是氢或化学式和--OR.sup.6的基团；R.sup.6，R.sup.6a和R.sup.6b分别是氢，羟基保护基团，烷基，烷烷基磺酰基，卤代烷烷基磺酰基或芳基磺酰基]及其盐和酯具有抑制胆固醇合成的能力，因此可用于治疗和预防高胆固醇血症和各种心脏疾病。
• Hexahydronaphthalene ester derivatives their preparation and their
  申请人：Sankyo Company, Limited

  公开号：US05827855A1

  公开（公告）日：1998-10-27

  Compounds of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is a group of formula --OR.sup.6 ; R.sup.6 is hydrogen; R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

  化合物的式子（I）：##STR1## 其中R.sup.1代表式子（II）或（III）的基团：##STR2## R.sup.2是烷基，烯基或炔基；R.sup.3和R.sup.4分别是氢，烷基，烯基或炔基；R.sup.5是氢或羧基保护基团；R.sup.a是式子--OR.sup.6的基团；R.sup.6是氢；R.sup.6a和R.sup.6b分别是氢，羟基保护基团，烷基，烷基磺酰，卤代烷基磺酰或芳基磺酰，以及它们的盐和酯。这些化合物抑制胆固醇的合成，可用于治疗和预防高胆固醇血症和各种心脏疾病。
• Hexanhydronaphthalene ester derivatives, their preparation and their therapeutic uses
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0605230A1

  公开（公告）日：1994-07-06

  Compounds of formula (I): [wherein R1 represents a group of formula (II) or (III): R2 is alkyl, alkenyl or alkynyl ; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl ; R5 is hydrogen or a carboxy-protecting group ; Ra is hydrogen or a group of formula and -OR6 ; R6, R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulphonyl, halogenated alkanesulphonyl or arylsulphonyl] and their salts and esters have the ability to inhibit the synthesis of cholesterol, and can thus be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

  式(I)化合物： [其中 R1 代表式 (II) 或 (III) 的基团： R2 是烷基、烯基或炔基；R3 和 R4 分别是氢、烷基、烯基或炔基；R5 是氢或羧基保护基团；Ra 是氢或式和 -OR6 的基团；R6、R6a 和 R6b 分别为氢、羟基保护基团、烷基、烷磺酰基、卤代烷磺酰基或芳基磺酰基]及其盐和酯具有抑制胆固醇合成的能力，因此可用于治疗和预防高胆固醇血症和各种心脏疾病。
• Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0605230B1

  公开（公告）日：1997-08-27
• US5451688A
  申请人：——

  公开号：US5451688A

  公开（公告）日：1995-09-19