(-)-(S)-cyclohexylammonium 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-3-phenylpropanoate | 1350846-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-(S)-cyclohexylammonium 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-3-phenylpropanoate
• 英文别名: (2S)-2-[4-[2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl]phenoxy]-3-phenylpropanoate;cyclohexylazanium
• CAS: 1350846-78-4
• 化学式: C₆H₁₃N*C₃₁H₃₆N₂O₄
• 分子量: 599.814
• InChiKey: KQVYIGLKGUWHDO-JMAPEOGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  44
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-苯基乳酸甲酯 在 Wilkinson's catalyst 、 硼烷四氢呋喃络合物 、 hydrazine hydrate 、 偶氮二甲酸二异丙酯 、 氢气 、 palladium diacetate 、 1-羟基苯并三唑 、 三乙胺 、 N,N-二异丙基乙胺 、 三苯基膦 、 三(邻甲基苯基)磷 、 sodium hydroxide 、 N,N'-二异丙基碳二亚胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 20.0 ℃ 、405.33 kPa 条件下， 反应 67.5h， 生成 (-)-(S)-cyclohexylammonium 2-(4-{2-[N-(heptyl)-N-(benzoxazol-2-yl)amino]ethyl}phenoxy)-3-phenylpropanoate
  参考文献：
  名称：

  Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity

  摘要：

  A series of ureidofibrate-like derivatives was prepared and assayed for their PPAR functional activity. A calorimetric approach was used to characterize PPAR gamma-ligand interactions, and docking experiments and X-ray studies were performed to explain the observed potency and efficacy. R-1 and S-1 were selected to evaluate several aspects of their biological activity. In an adipogenic assay, both enantiomers increased the expression of PPAR gamma target genes and promoted the differentiation of 3T3-L1 fibroblasts to adipocytes. In vivo administration of these compounds to insulin resistant C57Bl/6J mice fed a high fat diet reduced visceral fat content and body weight. Examination of different metabolic parameters showed that R-1 and S-1 are insulin sensitizers. Notably, they also enhanced the expression of hepatic PPAR alpha target genes indicating that their in vivo effects stemmed from an activation of both PPAR alpha and gamma. Finally, the capability of R-1 and S-1 to inhibit cellular proliferation in colon cancer cell lines was also evaluated.

  DOI：

  10.1021/jm201306q

文献信息

• Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity
  作者：L. Porcelli、F. Gilardi、A. Laghezza、L. Piemontese、N. Mitro、A. Azzariti、F. Altieri、L. Cervoni、G. Fracchiolla、M. Giudici、U. Guerrini、A. Lavecchia、R. Montanari、C. Di Giovanni、A. Paradiso、G. Pochetti、G. M. Simone、P. Tortorella、M. Crestani、F. Loiodice

  DOI：10.1021/jm201306q

  日期：2012.1.12

  A series of ureidofibrate-like derivatives was prepared and assayed for their PPAR functional activity. A calorimetric approach was used to characterize PPAR gamma-ligand interactions, and docking experiments and X-ray studies were performed to explain the observed potency and efficacy. R-1 and S-1 were selected to evaluate several aspects of their biological activity. In an adipogenic assay, both enantiomers increased the expression of PPAR gamma target genes and promoted the differentiation of 3T3-L1 fibroblasts to adipocytes. In vivo administration of these compounds to insulin resistant C57Bl/6J mice fed a high fat diet reduced visceral fat content and body weight. Examination of different metabolic parameters showed that R-1 and S-1 are insulin sensitizers. Notably, they also enhanced the expression of hepatic PPAR alpha target genes indicating that their in vivo effects stemmed from an activation of both PPAR alpha and gamma. Finally, the capability of R-1 and S-1 to inhibit cellular proliferation in colon cancer cell lines was also evaluated.