benzo[1,3]dioxol-4-yl-acetaldehyde | 62208-87-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: benzo[1,3]dioxol-4-yl-acetaldehyde
• 英文别名: 2-(2,3-methylenedioxyphenyl)acetaldehyde；1,3-Benzodioxole-4-acetaldehyde；2-(1,3-benzodioxol-4-yl)acetaldehyde
• CAS: 62208-87-1
• 化学式: C₉H₈O₃
• 分子量: 164.161
• InChiKey: FUCSPKRFPKVOKV-UHFFFAOYSA-N

物化性质

• 沸点：
  285.1±19.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzo[1,3]dioxol-4-yl-acetaldehyde 在 三甲基氯硅烷 、 三甲基溴硅烷 、 magnesium sulfate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 {2-Benzo[1,3]dioxol-4-yl-1-[(S)-2-biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-ethyl}-phosphonic acid
  参考文献：
  名称：

  Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11

  摘要：

  Structural modifications of CGS 26303, a non-peptidic alpha-aminophosphonate dual ECE/NEP inhibitor lead, were performed to maximize inhibition of recombinant human ECE-1, while maintaining strong NEP inhibition. Specifically, substitution of the a-aminophosphonate moiety with aryl ethyl sidechains led to the discovery of a new class of potent, non-peptidic, dual inhibitors, such as CGS 31447, which blocked ECE-1 and NEP activities with IC50's of 17 and 5 nM, respectively. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00159-5

文献信息

• [EN] BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS<br/>[FR] DERIVES DE BENZOFURANE UTILISES POUR TRAITER DES TROUBLES HYPERPROLIFERANTS
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2005014566A1

  公开（公告）日：2005-02-17

  The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.

  这项发明涉及到式(I)的新异环化合物，以及用于制备这些化合物的方法，以及它们用于制备治疗或预防疾病的药物，特别是治疗过度增殖性疾病的药物。
• [EN] BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS<br/>[FR] DERIVES DE BENZOFURANE ET DE BENZOTHIOPHENE UTILISES DANS LE TRAITEMENT DE TROUBLES HYPERPROLIFERATIFS
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2003072561A1

  公开（公告）日：2003-09-04

  This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

  这项发明涉及一般式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
• [EN] 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO<br/>[FR] DERIVES DE 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO-2,3-C PYRIDIN-2-YLMETHYL)PENTAN-2-OLE ET COMPOSES ASSOCIES EN TANT QUE LIGANDS DE GLUCOCORTICOIDES POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES ET DE DIABETE
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2005030213A1

  公开（公告）日：2005-04-07

  Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  式(I A)、(IB)、(IC)和(ID)的化合物，其中R1、R2、R3、R4、R5和R6分别如本文所定义的式(I A)、(IB)、(IC)和(ID)，或其互变异构体、前药、溶剂化合物或盐；含有这些化合物的药物组合物，以及利用这些化合物调节糖皮质激素受体功能的方法，以及利用这些化合物治疗由糖皮质激素受体功能介导或以炎症、过敏或增殖过程为特征的疾病状态或病情的方法。
• [EN] 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS<br/>[FR] DERIVES DE 1-PROPANOL ET 1-PROPYLAMINE ET LEUR UTILISATION EN TANT QUE LIGANDS DE GLUCOCORTICOIDE
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2004063163A1

  公开（公告）日：2004-07-29

  Compounds of Formula (I) wherein R1, R2 R3, R4, R5, R6, and X are as defiend herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocoricoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  式(I)的化合物，其中R1、R2、R3、R4、R5、R6和X如式(IA)和式(IB)中所定义，或其异构体、前药、溶剂化合物或盐；含有这些化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能的方法，以及使用这些化合物治疗由糖皮质激素受体功能介导或以炎症、过敏或增殖过程为特征的疾病状态或病况的方法。
• 6-[.alpha.-AMINO-.omega.-(2,3-METHYLENEDIOXYPH
  申请人：Richardson-Merrell Inc.

  公开号：US03994876A1

  公开（公告）日：1976-11-30

  Novel 6-[.alpha.-amino-.omega.-(2,3-methylenedioxyphenyl)acylamido] penicillanic acid derivatives are prepared which are useful as antibacterial agents.

  制备了6-[.alpha.-氨基-.omega.-(2,3-亚甲二氧基苯基)酰胺基]青霉烷酸衍生物，它们可用作抗菌剂。