(R)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone | 1372526-70-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone
• 英文别名: (4-chlorophenyl)-[3-[[3-[(2R)-oxiran-2-yl]phenyl]methoxy]phenyl]methanone
• CAS: 1372526-70-9
• 化学式: C₂₂H₁₇ClO₃
• 分子量: 364.828
• InChiKey: IOYDUUJPEYYRMP-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone 、 2-(4-甲氧苯基)乙胺 在 zinc perchlorate 作用下， 反应 1.0h， 以27%的产率得到(R)-(4-chlorophenyl)(3-((3-(2-hydroxy-1-((4-methoxyphenethyl)amino)ethyl)benzyl)oxy)phenyl)methanone
  参考文献：
  名称：

  Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

  摘要：

  Aurachin RE (1) is a strong antibiotic that was recently found to possess 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) and bacterial electron transport inhibitory activities. Aurachin RE is the only molecule in a series of aurachin natural products that has the chiral center in the alkyl side chain at C9'-position. To identify selective MenA inhibitors against Mycobacterium tuberculosis, a series of chiral molecules were designed based on the structures of previously identified MenA inhibitors and 1. The synthesized molecules were evaluated in in vitro assays, including MenA enzyme and bacterial growth inhibitory assays. We could identify novel MenA inhibitors that showed significant increase in potency of killing nonreplicating M. tuberculosis in the low oxygen recovery assay (LORA) without inhibiting other Gram-positive bacterial growth even at high concentrations. The MenA inhibitors reported here are useful new pharmacophores for the development of selective antimycobacterial agents with strong activity against nonreplicating M. tuberculosis.

  DOI：

  10.1021/jm201608g
• 作为产物：
  描述：

  4-氯-N-甲氧基-N-甲基乙酰胺 在 potassium peroxymonosulfate 、 1,1,1-三氟丙酮 、 偶氮二甲酸二异丙酯 、 (S,S)-Salen Co(II) 、 氢溴酸 、 异丙基氯化镁 、 edetate disodium 、 碳酸氢钠 、 溶剂黄146 、 三苯基膦 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 52.5h， 生成 (R)-(4-chlorophenyl)(3-((3-(oxiran-2-yl)benzyl)oxy)phenyl)methanone
  参考文献：
  名称：

  Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

  摘要：

  Aurachin RE (1) is a strong antibiotic that was recently found to possess 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) and bacterial electron transport inhibitory activities. Aurachin RE is the only molecule in a series of aurachin natural products that has the chiral center in the alkyl side chain at C9'-position. To identify selective MenA inhibitors against Mycobacterium tuberculosis, a series of chiral molecules were designed based on the structures of previously identified MenA inhibitors and 1. The synthesized molecules were evaluated in in vitro assays, including MenA enzyme and bacterial growth inhibitory assays. We could identify novel MenA inhibitors that showed significant increase in potency of killing nonreplicating M. tuberculosis in the low oxygen recovery assay (LORA) without inhibiting other Gram-positive bacterial growth even at high concentrations. The MenA inhibitors reported here are useful new pharmacophores for the development of selective antimycobacterial agents with strong activity against nonreplicating M. tuberculosis.

  DOI：

  10.1021/jm201608g

文献信息

• Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis
  作者：Joy Debnath、Shajila Siricilla、Bajoie Wan、Dean C. Crick、Anne J. Lenaerts、Scott G. Franzblau、Michio Kurosu

  DOI：10.1021/jm201608g

  日期：2012.4.26

  Aurachin RE (1) is a strong antibiotic that was recently found to possess 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA) and bacterial electron transport inhibitory activities. Aurachin RE is the only molecule in a series of aurachin natural products that has the chiral center in the alkyl side chain at C9'-position. To identify selective MenA inhibitors against Mycobacterium tuberculosis, a series of chiral molecules were designed based on the structures of previously identified MenA inhibitors and 1. The synthesized molecules were evaluated in in vitro assays, including MenA enzyme and bacterial growth inhibitory assays. We could identify novel MenA inhibitors that showed significant increase in potency of killing nonreplicating M. tuberculosis in the low oxygen recovery assay (LORA) without inhibiting other Gram-positive bacterial growth even at high concentrations. The MenA inhibitors reported here are useful new pharmacophores for the development of selective antimycobacterial agents with strong activity against nonreplicating M. tuberculosis.