5-Dichlorophosphoryloxy-6,7-diphenylpyrrolo[1,2-b]pyridazine | 332123-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 5-Dichlorophosphoryloxy-6,7-diphenylpyrrolo[1,2-b]pyridazine
• CAS: 332123-88-3
• 化学式: C₁₉H₁₃Cl₂N₂O₂P
• 分子量: 403.204
• InChiKey: PXWIEBGWWDVIMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙醇 、 5-Dichlorophosphoryloxy-6,7-diphenylpyrrolo[1,2-b]pyridazine 反应 24.0h， 生成 diethyl 6,7-diphenylpyrrolo[1,2-b]pyridazin-5-yl phosphate
  参考文献：
  名称：

  Synthesis of 5-Substituted Pyrrolo[1,2-b]pyridazines with Antioxidant Properties

  摘要：

  5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.

  DOI：

  10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w
• 作为产物：
  描述：

  二苯基环丙烯酮 在 三氯氧磷 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 5.0h， 生成 5-Dichlorophosphoryloxy-6,7-diphenylpyrrolo[1,2-b]pyridazine
  参考文献：
  名称：

  Synthesis of 5-Substituted Pyrrolo[1,2-b]pyridazines with Antioxidant Properties

  摘要：

  5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.

  DOI：

  10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w

文献信息

• Synthesis of 5-Substituted Pyrrolo[1,2-b]pyridazines with Antioxidant Properties
  作者：Ole Benny Østby、Lise-Lotte Gundersen、Frode Rise、Øyvind Antonsen、Kjetil Fosnes、Vibeke Larsen、Aalt Bast、Ilse Custers、Guido R. M. M. Haenen

  DOI：10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w

  日期：2001.1

  5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.