dodecanoic acid 2-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyloxy)-ethoxy]-ethyl ester | 702701-56-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dodecanoic acid 2-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyloxy)-ethoxy]-ethyl ester
• 英文别名: 2-[2-(2,5-Dioxopyrrolidin-1-yl)oxycarbonyloxyethoxy]ethyl dodecanoate
• CAS: 702701-56-2
• 化学式: C₂₁H₃₅NO₈
• 分子量: 429.511
• InChiKey: QCPQKTPNZOREOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N,N'-二琥珀酰亚胺基碳酸酯 、 聚乙二醇(400)月桂酸酯 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 16.17h， 以83%的产率得到dodecanoic acid 2-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyloxy)-ethoxy]-ethyl ester
  参考文献：
  名称：

  Bna Conjugates and Methods of Use

  摘要：

  本发明公开了改性利钠肽化合物及其共轭物。具体而言，提供了至少连接有一个修饰基团的hBNP的共轭形式。这些改性利钠肽化合物共轭物保留了刺激cGMP产生、结合NPR-A受体、降低动脉血压以及在某些实施例中相对于未经改性的对应利钠肽化合物具有改善的循环半衰期的活性。这些化合物和共轭物的口服、静脉注射、肠内、皮下、肺部和静脉形式可作为治疗和/或治疗心脏病症，特别是充血性心力衰竭的治疗。还公开了包含具有各种长度和构型的寡聚结构的修饰基团。此外，还公开了hBNP化合物的类似物，其氨基酸序列与天然序列不同。

  公开号：

  US20080207505A1

文献信息

• NATRIURETIC COMPOUNDS, CONJUGATES, AND USES THEREOF
  申请人：James Kenneth D.

  公开号：US20100216714A1

  公开（公告）日：2010-08-26

  Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.
• US7648962B2
  申请人：——

  公开号：US7648962B2

  公开（公告）日：2010-01-19
• US7662773B2
  申请人：——

  公开号：US7662773B2

  公开（公告）日：2010-02-16
• [EN] BNP CONJUGATES AND METHODS OF USE<br/>[FR] CONJUGUES BNP ET PROCEDES D'UTILISATION
  申请人：NOBEX CORP

  公开号：WO2006076471A2

  公开（公告）日：2006-07-20

  [EN] Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of liBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, decreasing arterial blood pressure and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the hBNP compound are also disclosed, having an amino acid sequence that is other than the native sequence.
  [FR] Cette invention se rapporte à des composés natriurétiques modifiés et à leurs conjugués. L'invention concerne notamment des formes conjuguées de hBNP auxquelles est attaché au moins un groupe caractéristique de modification. Les conjugués de composés natriurétiques modifiés fixent l'activité de stimulation de production de cGMP, de liaison au récepteur NPR-A, de baisse de la tension artérielle et présentent, dans certains modes de réalisation, une demi-vie plus longue en circulation par rapport à leurs homologues natriurétiques non modifiés. On peut préparer des formes orales, parentérales, entérales, sous-cutanées, pulmonaires ou intraveineuses desdits composés ou conjugués, utilisées comme agents de traitement et/ou thérapeutiques pour des maladies cardiaques, notamment en cas d'insuffisance cardiaque globale. L'invention porte aussi sur des groupes caractéristiques de modification qui comprennent des structures oligomères de longueurs et de configurations diverses. L'invention concerne également des analogues du composé hBNP ayant une séquence d'acides aminés différente de la séquence native. .
• Bna Conjugates and Methods of Use
  申请人：James Kenneth D.

  公开号：US20080207505A1

  公开（公告）日：2008-08-28

  Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, decreasing arterial blood pressure and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, enteral, subcutaneous, pulmonary, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the hBNP compound are also disclosed, having an amino acid sequence that is other than the native sequence.

  本发明公开了改性利钠肽化合物及其共轭物。具体而言，提供了至少连接有一个修饰基团的hBNP的共轭形式。这些改性利钠肽化合物共轭物保留了刺激cGMP产生、结合NPR-A受体、降低动脉血压以及在某些实施例中相对于未经改性的对应利钠肽化合物具有改善的循环半衰期的活性。这些化合物和共轭物的口服、静脉注射、肠内、皮下、肺部和静脉形式可作为治疗和/或治疗心脏病症，特别是充血性心力衰竭的治疗。还公开了包含具有各种长度和构型的寡聚结构的修饰基团。此外，还公开了hBNP化合物的类似物，其氨基酸序列与天然序列不同。