4-ethylsulfanyl-2-oxo-butyric acid | 36506-17-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-ethylsulfanyl-2-oxo-butyric acid
• 英文别名: 4-Aethylmercapto-2-oxo-buttersaeure；4-(Ethylsulfanyl)-2-oxobutanoic acid；4-ethylsulfanyl-2-oxobutanoic acid
• CAS: 36506-17-9
• 化学式: C₆H₁₀O₃S
• 分子量: 162.21
• InChiKey: NGPOXPZQRGMRIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  271.6±23.0 °C(Predicted)
• 密度：
  1.216±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  D-乙硫氨基酪酸 在 D-amino acid:oxygen-oxidoreduktase 作用下， 生成 4-ethylsulfanyl-2-oxo-butyric acid
  参考文献：
  名称：

  Meister, Journal of Biological Chemistry, 1952, vol. 197, p. 309,313

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR PRODUCING SULFUR-CONTAINING AMINO ACID OR SALT THEREOF<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN ACIDE AMINÉ CONTENANT DU SOUFRE OU DE L'UN DE SES SELS
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2011118849A1

  公开（公告）日：2011-09-29

  According to the present invention, a new process for producing a sulfur-containing amino acid without using of hydrogen cyanide or sodium azide which requires careful handling as a raw material can be provided. The present invention relates to a process for producing a sulfur-containing amino acid represented by the following formula (1) or a salt thereof: wherein R1 is an alkyl group having 1 to 12 carbon atoms and optionally having substituents or a cycloalkyl group having 3 to 12 carbon atoms and optionally having substituents, and n is an integral number of from 1 to 4, comprising a step of reacting a sulfur-containing 2-ketocarboxylic acid represented by the formula (2) or a salt thereof: wherein R1 and n mean the same as defined above, with ammonia and hydrogen in the presence of a transition metal catalyst.

  根据本发明，可以提供一种新的生产含硫氨基酸的方法，而不需要使用需要小心处理的氢氰酸或偏氮化钠作为原料。本发明涉及一种生产以下式（1）或其盐所表示的含硫氨基酸的方法：其中R1是具有1至12个碳原子并可选择具有取代基的烷基或具有3至12个碳原子并可选择具有取代基的环烷基，n是从1至4的整数，包括以下步骤：在过渡金属催化剂的存在下，将以下式（2）或其盐所表示的含硫2-酮羧酸与氨和氢反应。其中R1和n的含义如上所定义。
• [EN] PROCESS FOR PREPARING SULFUR-CONTAINING 2-KETOCARBOXYLATE COMPOUND<br/>[FR] PROCÉDÉ POUR PRÉPARER UN COMPOSÉ 2-CÉTOCARBOXYLATE CONTENANT DU SOUFRE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2012026619A1

  公开（公告）日：2012-03-01

  The present invention provides a novel process for preparing a sulfur-containing 2-ketocarboxylate compound without using any enzyme. The process comprises a step of oxidizing a hydroxyacetate compound having an optionally-substituted sulfur-containing hydrocarbon group at 2-position in the presence of a vanadium compound. Preferably, the step is carried out further in the presence of oxygen, and more preferably, in the presence of an organic solvent.

  本发明提供了一种新型的制备含硫2-酮羧酸酯化合物的方法，不需要使用任何酶。该方法包括在钒化合物存在的情况下氧化2-位置具有可选取代硫代烃基的羟基乙酸化合物的步骤。最好在氧气存在的情况下进行该步骤，更好的是在有机溶剂存在的情况下进行。
• L-phenylalanine dehydrogenase and use thereof
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0206460A2

  公开（公告）日：1986-12-30

  New L-phenylalanine dehydrogenases produced by a microorganism belonging to the genus Sporosarcina or Bacillus, new microorganisms capable of L-phenylalanine dehydrogenase and belonging to the genus Sporosarcina or Bacillus, a process for production of L-phenylalanine dehydrogenase using the microorganisms, and processes for production of L-amino acids using the enzymes or the microorganisms.

  由属于孢子丝菌属或芽孢杆菌属的微生物产生的新型 L-苯丙氨酸脱氢酶，能够产生 L-苯丙氨酸脱氢酶且属于孢子丝菌属或芽孢杆菌属的新型微生物，使用该微生物生产 L-苯丙氨酸脱氢酶的工艺，以及使用该酶或该微生物生产 L-氨基酸的工艺。
• OXIDASE, POLYNUCLEOTIDE THAT CODES FOR SAME, AND USES FOR BOTH
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3168302A1

  公开（公告）日：2017-05-17

  A polynucleotide encoding an amino acid sequence represented by SEQ ID NO: 1 or 3; a protein having an amino acid sequence represented by SEQ ID NO: 1 or 3; and; a method for producing an L-α-amino acid compound, which comprises the step (1) for reacting the present invented protein with an α-hydroxycarboxylic acid compound to obtain a corresponding α-oxocarboxylic acid compound, and the step of reacting a protein having the ability to aminate an α-oxocarboxylic acid compound and convert the same into a corresponding L-α-amino acid compound with the α-oxocarboxylic acid compound obtained in the step (1) to obtain a corresponding L-α-amino acid compound; and the like.

  编码由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的多核苷酸；具有由 SEQ ID NO：1或3所代表的氨基酸序列的蛋白质；以及一种生产 L-α-氨基酸化合物的方法，该方法包括步骤(1)，将本发明的蛋白质与 α-羟基羧酸化合物反应，得到相应的 α-氧代羧酸化合物、以及将具有氨化α-氧羧酸化合物并将其转化为相应的 L-α-氨基酸化合物的能力的蛋白质与步骤（1）中获得的α-氧羧酸化合物反应，以获得相应的 L-α-氨基酸化合物的步骤；等。
• Oxidase, polynucleotide that codes for same, and use thereof
  申请人：Sumitomo Chemical Company

  公开号：US10351829B2

  公开（公告）日：2019-07-16

  A polynucleotide encoding an amino acid sequence represented by SEQ ID NO: 1 or 3; a protein having an amino acid sequence represented by SEQ ID NO: 1 or 3; and a method for producing an L-α-amino acid compound are provided. The method includes a step (1) of reacting the protein described herein with an α-hydroxycarboxylic acid compound to obtain a corresponding α-oxocarboxylic acid compound; and a step of reacting a protein having the ability to aminate an α-oxocarboxylic acid compound and convert the same into a corresponding L-α-amino acid compound with the α-oxocarboxylic acid compound obtained in step (1) to obtain a corresponding L-α-amino acid compound.

  本发明提供了一种编码由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的多核苷酸；一种具有由 SEQ ID NO: 1 或 3 所代表的氨基酸序列的蛋白质；以及一种生产 L-α-氨基酸化合物的方法。该方法包括步骤(1)，将本文所述的蛋白质与α-羟基羧酸化合物反应，得到相应的α-氧代羧酸化合物；以及步骤(2)，将具有氨化α-氧代羧酸化合物并将其转化为相应的L-α-氨基酸化合物的能力的蛋白质与步骤(1)中得到的α-氧代羧酸化合物反应，得到相应的L-α-氨基酸化合物。