5-异丙基-1H-2-吲哚甲酸 | 383132-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-异丙基-1H-2-吲哚甲酸
• 中文别名: 5-异丙基-1H-吲哚-2-羧酸
• 英文名称: 5-isopropyl-1H-indole-2-carboxylic acid
• 英文别名: 5-propan-2-yl-1H-indole-2-carboxylic acid
• CAS: 383132-39-6
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.24
• InChiKey: FUOMWKBVELXWCU-UHFFFAOYSA-N

物化性质

• 沸点：
  411.7±25.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P280
• 危险性描述：
  H302,H317

文献信息

• NOVEL AMINE DERIVATIVE HAVING HUMAN BETA-TRYPTASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1445250A1

  公开（公告）日：2004-08-11

  It is intended to provide a novel low-molecular weight amine derivative, that is absorbed well, has low toxicity, and has an excellent human β-tryptase inhibitory activity with extremely high selectivity, a pharmaceutically acceptable salt thereof, and a medicine containing the same as an active ingredient. The medicine of the present invention is efficacious as a prophylactic/therapeutic agent for diseases in the crisis and evolution of which are considered to be attributed to β-tryptase, for example, respiratory diseases, allergic diseases, inflammatory bowel diseases, hyperprolliferative skin diseases, vascular edema and rheumatoid arthritis.

  本发明旨在提供一种新型低分子量胺衍生物，该衍生物被很好地吸收，毒性低，并且具有极高选择性的优异人类β-色氨酸蛋白酶抑制活性，其药学上可接受的盐，以及含有该衍生物作为活性成分的药物。本发明的药物可作为一种预防/治疗剂，用于被认为是由β-色氨酸蛋白酶引起的危机和发展的疾病，例如呼吸道疾病、过敏性疾病、炎症性肠病、皮肤过度增生疾病、血管水肿和类风湿性关节炎。
• INDOLE COMPOUND AND MEDICINAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：EP1452526A1

  公开（公告）日：2004-09-01

  An indole compound represented by the formula (1) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof or a prodrug thereof is useful as a therapeutic agents for diabetes having an HLGPa inhibitory activity.

  由公式（1）表示的吲哚化合物，其中每个符号如规范中定义，其药用盐或其前药是作为具有HLGPa抑制活性的糖尿病治疗剂。
• [EN] SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] INDOLES SUBSTITUES DOTES D'UNE AFFINITE POUR LE RECEPTEUR DE LA SEROTONINE, LEUR PROCEDE DE FABRICATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2004108671A1

  公开（公告）日：2004-12-16

  The present invention relates to the compounds represented by general formula (I) as shown below.

  本发明涉及如下所示的一般式(I)所代表的化合物。
• Indole compounds and medicinal use thereof
  申请人：Nakamura Takeshi

  公开号：US20050054696A1

  公开（公告）日：2005-03-10

  An indole compound represented by the formula (1) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof or a prodrug thereof is useful as a therapeutic agents for diabetes having an HLGPa inhibitory activity.

  一种吲哚化合物，其化学式表示为（1），其中每个符号的定义如规范中所述，其药物可接受的盐或前药，可用作具有HLGPa抑制活性的糖尿病治疗剂。
• ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR
  申请人：Buchmann Bernd

  公开号：US20090023741A1

  公开（公告）日：2009-01-22

  The present invention relates to aryl/hetarylamide derivatives of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP 2 receptor.

  本发明涉及通式I的芳基/杂环酰胺衍生物，其制备方法，以及用于制造治疗与EP2受体相关的疾病和适应症的药物组合物的用途。