Methylnaloxonium | 73232-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Methylnaloxonium
• 英文别名: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one
• CAS: 73232-50-5
• 化学式: C20H24NO4+
• 分子量: 342.4
• InChiKey: PCSQOABIHJXZMR-MGQKVWQSSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions Comprising Enzyme-Cleavable Phenol-Modified Opioid Prodrugs and Inhibitors Thereof
  申请人：Jenkins Thomas E.

  公开号：US20110262360A1

  公开（公告）日：2011-10-27

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.

  提供了药物组合物及其使用方法，其中药物组合物包括一种苯酚修饰的阿片类前药，该前药提供酶控制释放苯酚类阿片类药物，并且包括与介导苯酚修饰的阿片类前药酶控制释放的酶相互作用的酶抑制剂，以调节苯酚修饰的阿片类前药的酶解。
• PAIN-RELATED COMPOUND AND MEDICAL COMPOSITION
  申请人：KYOTO UNIVERSITY

  公开号：US20170029389A1

  公开（公告）日：2017-02-02

  Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

  提供了一种与疼痛有关的化合物、与疼痛有关的药物组合物及其使用。在一种或多种实施例中，提供了一种由公式（I）表示的化合物，其前药，或任何其中的药用允许的盐。
• Pharmaceutical Compositions with Attenuated Release of Phenolic Opioids
  申请人：Jenkins Thomas E.

  公开号：US20110281886A1

  公开（公告）日：2011-11-17

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

  本发明提供了一种药物组合物及其使用方法，其中药物组合物包括一种酚类阿片类前药，该前药提供酶控释酚类阿片类药物，以及一种酶抑制剂，该酶抑制剂与介导酚类阿片类前药酶控释酚类阿片类药物的酶相互作用，以减弱前药的酶解。
• PAIN-RELATED COMPOUND AND MEDICINAL COMPOSITION
  申请人：Kyoto University

  公开号：EP3085698A1

  公开（公告）日：2016-10-26

  Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

  本发明提供了一种疼痛相关化合物、一种疼痛相关药物组合物及其用途。在一个或多个实施例中，提供了一种由式（I）代表的化合物、其原药或其药学上允许的盐。
• VERFAHREN ZUR REINIGUNG VON NOROXYMORPHON-VERBINDUNGEN
  申请人：Cilag AG

  公开号：EP1851226B1

  公开（公告）日：2014-11-26