1,1-diphenyl-N-(1-phenylpropyl)methanimine | 179320-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-diphenyl-N-(1-phenylpropyl)methanimine
• CAS: 179320-56-0
• 化学式: C₂₂H₂₁N
• 分子量: 299.415
• InChiKey: RKWITCOENPVEMK-UHFFFAOYSA-N

物化性质

• 沸点：
  407.8±28.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-diphenyl-N-(1-phenylpropyl)methanimine 在 盐酸 作用下， 以 various solvent(s) 为溶剂， 反应 16.0h， 生成 1-苯基丙-1-胺
  参考文献：
  名称：

  Revisiting optically active quaternary derivatives made from prolinol as phase transfer catalysts

  摘要：

  New non-racemic ammonium salts derived from prolinol have been prepared which are stereogenic both at N and at C. Absolute configurations rest on X-ray structures for 3c and 7a. The new compounds have been tested in a number of known enantioselective phase transfer catalytic (PTC) reactions to gain insight into steric control factors in such processes. Only very moderate e.e.s were observed. A SAMP hydrazone related catalyst (7a) reported by other authors was fully characterized. Racemic reaction products were obtained in two alkylations of diphenylmethylene benzylimine in the presence of this pure catalyst 7a. Very high e.e.s reported previously by others could not be reproduced. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00213-4
• 作为产物：
  描述：

  二苯甲胺 在 potassium tert-butylate 、 magnesium sulfate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.75h， 生成 1,1-diphenyl-N-(1-phenylpropyl)methanimine
  参考文献：
  名称：

  Efficient Transamination under Mild Conditions:  Preparation of Primary Amine Derivatives from Carbonyl Compounds via Imine Isomerization with Catalytic Amounts of Potassium tert-Butoxide

  摘要：

  1,3-Prototropic rearrangement of N-diphenylmethanimines was successfully performed with a catalytic amount of potassium tert-butoxide. This procedure can also be used with aliphatic and aromatic aldimines and was extended to the isomerization of (1R)-camphorquinone monoimine and N-(4-methoxyphenyl)-4-phenyl-3-iminoazetidin-2-one. The isomerized imines were easily hydrolyzed and isolated as Cbz derivatives.

  DOI：

  10.1021/jo952124d

文献信息

• Electrochemical Ni‐Catalyzed Decarboxylative C(sp³)−N Cross‐Electrophile Coupling
  作者：Yue‐Ming Cai、Xiao‐Ting Liu、Lin‐Lin Xu、Ming Shang

  DOI：10.1002/anie.202315222

  日期：2024.3.18

  Ni-catalyzed decarboxylative C(sp3)−N cross-coupling of redox active ester and oxime esters was realized through electrochemical cathodic reduction. Mechanistic studies unveil a high-valent nickel species-driven reductive elimination pathway, rather than direct radical-radical coupling. The utility of this methodology was demonstrated through a broad scope (1°, 2°, 3° carboxylic acids) and late-stage

  通过电化学阴极还原实现了氧化还原活性酯和肟酯的镍催化脱羧C(sp 3 )−N交叉偶联。机理研究揭示了高价镍物质驱动的还原消除途径，而不是直接的自由基-自由基耦合。该方法的实用性通过复杂分子的广泛范围（1°、2°、3°羧酸）和后期功能化得到了证明。