sodium N-(3-acetamidopropyl)dithiocarbamate | 74651-80-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: sodium N-(3-acetamidopropyl)dithiocarbamate
• 英文别名: sodium;N-(3-acetamidopropyl)carbamodithioate
• CAS: 74651-80-2
• 化学式: C₆H₁₁N₂OS₂*Na
• 分子量: 214.288
• InChiKey: AWTAQWODGLVZNI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.06
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  74.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium N-(3-acetamidopropyl)dithiocarbamate 、 N-乙酰基-1,3-丙二胺 、 碘甲烷 在 二硫化碳 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 生成 methyl N-(3-acetamidopropyl)dithiocarbamate
  参考文献：
  名称：

  Cephem and cepham compounds

  摘要：

  这项发明涉及具有高抗微生物活性的新型7-噻二唑氧肟基-3-头孢菌素和头孢菌素-4-羧酸化合物。

  公开号：

  US04390534A1

文献信息

• 7-[2-Alkoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl)acetamido]-3-cephems
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04447429A1

  公开（公告）日：1984-05-08

  This invention relates to novel cephem compounds of high antimicrobial activity of the formula ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is lower alkyl, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen, acyloxy(lower)alkyl or acylthio(lower)alkyl and R.sup.5 is carboxy or a protected carboxy.

  本发明涉及高抗微生物活性的新型头孢菌素化合物，其化学式为##STR1##其中R.sup.1为氨基或保护氨基，R.sup.2为低碳基，R.sup.3为氢或低碳基，R.sup.4为氢，酰氧（低）碳基或酰硫（低）碳基，R.sup.5为羧基或保护羧基。
• 7-[Amino or carboxy substituted oxyimino]-3-[amino or alkoxy substituted
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04487767A1

  公开（公告）日：1984-12-11

  Bacteriostatic cephem compounds and processes for preparing same having the formula: ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkyl, esterified carbony(lower)alkyl, (C.sub.3 -C.sub.8)cycloalkyl, lower alkenyl or lower alkynyl, R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)alkyl, hydroxy(lower)alkyl or both amino and lower alkyl, R.sup.4 is carboxy or protected carboxy, provided that R.sup.3 is a heterocyclic group substituted with hydroxy(lower)alkyl or both amino and lower alkyl, when R.sup.2 is lower alkyl, and its pharmaceutically acceptable salt.

  具有以下结构式的抑菌头孢烯类化合物和制备方法：##STR1## 其中，R.sup.1是氨基或受保护的氨基，R.sup.2是较低的烷基，氨基（较低）烷基，受保护的氨基（较低）烷基，羟基（较低）烷基，受保护的羟基（较低）烷基，较低烷基硫（较低）烷基，羧基（较低）烷基，酯化的羰基（较低）烷基，（C.sub.3-C.sub.8）环烷基，较低烯基或较低炔基，R.sup.3是带有氨基（较低）烷基，受保护的氨基（较低）烷基，羟基（较低）烷基或氨基和较低烷基的取代的杂环基，R.sup.4是羧基或受保护的羧基，但当R.sup.3是带有羟基（较低）烷基或氨基和较低烷基的取代的杂环基时，R.sup.2是较低烷基，以及其药学上可接受的盐。
• New cephem compounds and processes for preparation thereof
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04268509A1

  公开（公告）日：1981-05-19

  This invention relates to new 7-substituted-3-cephem-4-carboxylic acids and pharmaceutically acceptable salts thereof, which have antimicrobial activities, and processes for preparation thereof, to intermediates for preparing the same and processes for preparation thereof, and to pharmeceutical compositions comprising the same and methods of using the same prophylactically and therapeutically for treatment of infectious diseases in human beings and animals.

  本发明涉及新的7-取代-3-头孢烷-4-羧酸及其药学上可接受的盐，具有抗微生物活性，并提供其制备方法，制备中间体的方法，以及包含其的药学组合物和用于预防和治疗人类和动物感染性疾病的方法。
• Cephem intermediates
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04585872A1

  公开（公告）日：1986-04-29

  Alkoxyimino-2-(5-amino-1,2,4-thiadiazol-3-yl) acetic acid compounds are intermediates for cephem compounds.

  Alkoxyimino-2-(5-amino-1,2,4-噻二唑-3-基)乙酸化合物是头孢菌素化合物的中间体。
• Cephem compounds
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04341775A1

  公开（公告）日：1982-07-27

  Bacteriostatic cephem compounds and processes for preparing same having the formula: ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is lower alkyl, amino-(lower)-alkyl, protected amino-(lower)-alkyl, hydroxy-(lower)-alkyl, protected hydroxy-(lower)-alkyl, lower alkylthio-(lower)-alkyl, carboxy-(lower)-alkyl, esterified carboxy-(lower)-alkyl, (C.sub.3 to C.sub.8) cycloalkyl, lower alkenyl or lower alkynyl, R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)-alkyl, hydroxy(lower)alkyl or both amino and lower alkyl, R.sup.4 carboxy or protected carboxy, provided that R.sup.3 is a heterocyclic group substituted with hydroxy(lower)alkyl or both amino and lower alkyl, when R.sup.2 is lower alkyl, and its pharmaceutically acceptable salt.

  具有以下公式的细菌抑制性头孢烯化合物及其制备方法：##STR1##其中R.sup.1是氨基或保护的氨基，R.sup.2是低碳基，氨基-(低)-烷基，保护的氨基-(低)-烷基，羟基-(低)-烷基，保护的羟基-(低)-烷基，低硫基-(低)-烷基，羧基-(低)-烷基，酯化羧基-(低)-烷基，(C.sub.3至C.sub.8)环烷基，低烯基或低炔基，R.sup.3是杂环基，被氨基(低)烷基，保护的氨基(低)-烷基，羟基(低)烷基或氨基和低碳基取代，R.sup.4是羧基或保护的羧基，但当R.sup.2是低碳基时，R.sup.3是被羟基(低)烷基或氨基和低碳基取代的杂环基，以及其药学上可接受的盐。