Linoleate | 1509-85-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Linoleate
• 英文别名: (9Z,12Z)-octadeca-9,12-dienoate
• CAS: 1509-85-9
• 化学式: C18H31O2-
• 分子量: 279.4
• InChiKey: OYHQOLUKZRVURQ-HZJYTTRNSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Linoleate 生成 9-cis,11-trans-Octadecadienoate
  参考文献：
  名称：

  Kepler C.R.; Tove S.B., J Biol Chem, 1967, 0021-9258, 5686-92

  摘要：

  DOI：
• 作为产物：
  描述：

  水 、 亚油醇乙醇胺 生成 Linoleate 、 2-amino-ethanol; protonated form
  参考文献：
  名称：

  N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

  摘要：

  中，C. elegans是一种重要的衰老研究模型。

  DOI：

  10.1038/nature10007

文献信息

• Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms
  作者：Alexandra-Zoi Andreou、Marian Vanko、Lydia Bezakova、Ivo Feussner

  DOI：10.1016/j.phytochem.2008.03.002

  日期：2008.6

  linoleic acid esterified to a bulky phosphatidylcholine molecule as a substrate suggested a tail-fist binding orientation of the substrate. Site directed mutagenesis of the alanine to glycine did not cause alterations in the stereospecificity of the products, while mutation of the alanine to valine or isoleucine modified both regio- and enantioselectivity of the enzyme. Kinetic measurements revealed

  脂氧合酶 (LOX) 由一类催化多不饱和脂肪酸的区域和立体定向双加氧的酶组成。目前的报道提出，R-脂肪氧化酶活性位点的保守甘氨酸残基和S-脂肪氧化酶相应位置的丙氨酸残基在决定产物的立体化学方面起着至关重要的作用。最近，来自 Nostoc sp. 的具有亚油酸二醇合酶活性的双功能脂肪氧化酶。鉴定了具有 R 立体特异性的 PCC7120 和迄今为止在手性特异性序列决定簇位置携带丙氨酸而不是保守甘氨酸的独特特征。在大肠杆菌中表达后纯化重组羧基末端结构域。该酶使用酯化为庞大的磷脂酰胆碱分子的亚油酸作为底物的能力表明底物的尾拳结合方向。将丙氨酸定点诱变为甘氨酸不会引起产物立体特异性的改变，而将丙氨酸突变为缬氨酸或异亮氨酸改变了酶的区域选择性和对映选择性。动力学测量表明，用 Gly 或 Val 取代 Ala 不会显着影响反应特性，而 A162I 突变体显示 vmax 降低。根据获得的诱变数据，
• Liquid skin treatment
  申请人：——

  公开号：US20010001666A1

  公开（公告）日：2001-05-24

  A composition for the maintenance of smooth, radiant, hydrated skin, including sufficient amounts of acids of hydroxyacid, to facilitate exfoliation of skin in a novel manner, without substantial irritation, as well as the prevention, treatment and management of skin conditions, such as acne, wrinkled, irregularly pigmented, photoaged, and thickened layers of the epidermis, and the like, which has as its constituents, safflower oil, flaxseed oil, sweet almond oil, apricot kernel oil, jojoba oil, organic beeswax, stearic acid, cetearyl alcohol, cocoa butter, vitamin A and tocopheral linoleate, borax, oil of lavender, and tincture of benzoin as an antimicrobial agent.

  这是一种用于维持光滑、明亮、水润皮肤的配方，包括足够量的羟基酸，以新颖的方式促进皮肤的去角质，而不会引起明显的刺激，同时还可以预防、治疗和管理皮肤状况，如痤疮、皱纹、色素不均、光老化和表皮增厚等。该配方的成分包括红花籽油、亚麻籽油、甜杏仁油、杏仁油、有机蜂蜡、硬脂酸、十六醇、可可脂、维生素A和亚油酸生育酚酯、硼砂、薰衣草油和苯甲酸酊作为抗微生物剂。
• Foot cream composition
  申请人：——

  公开号：US20010005509A1

  公开（公告）日：2001-06-28

  An improved, and useful, topical transdermal delivery composition for the alleviation and treatment of dermatitis, eczema, lupus, dry, cracked, flaking, peeling, and itching skin infirmites of the foot, which has as its constituents, safflower oil, flaxseed oil, vitamin A, tocopheryl linoleate, and tincture of benzoin to restore organic oil lipids that are essential for the health of the dermal areas of the foot.

  一种改进的、有用的局部经皮递送组合物，用于缓解和治疗皮炎、湿疹、狼疮、干燥、龟裂、剥落和瘙痒的脚部皮肤病，其成分包括红花籽油、亚麻籽油、维生素A、亚油酸生育酚酯和苯甲酊浸膏，以恢复对脚部皮肤健康至关重要的有机油脂。
• Partial esters of epoxy containing compounds
  申请人：Elf Atochem North America, Inc.

  公开号：US05324846A1

  公开（公告）日：1994-06-28

  The present invention relates to a partial ester derived from the reaction product of an oxirane containing acid or derivative thereof, and a reactive hydroxyl compound selected from the group consisting of diols, triols, di-diols and 1,4-dihydroxy butane and a halogen containing polymer compositon thereof. The oxirane compound can be derived from the group consisting of epoxidized vegetable oil, epoxidized fish oil, an aliphatic or arylaliphatic containing craboxyl compound having an oxirane group in the aliphatic chain.

  本发明涉及一种部分酯，其由含有酸性或其衍生物的环氧乙烷和从二元醇、三元醇、二元二醇和1,4-双羟基丁烷中选择的反应性羟基化合物的反应产物派生，并与含卤素的聚合物复合物一起使用。环氧乙烷化合物可以来自经环氧化的植物油、经环氧化的鱼油、具有脂肪链中的环氧乙烷基的脂肪族或芳香族羧酸化合物的羧酸化合物。
• REFINED PLANT OILS FREE OF GLYCIDYL ESTERS
  申请人：Craft Brian

  公开号：US20140018561A1

  公开（公告）日：2014-01-16

  The present invention generally relates to the field of oil refinement. In particular, the present invention relates to the field of processes to produce refined oils, substantially free of contaminants, such as glycidyl esters, for example. In accordance with the present invention, such refined plant oils free of glycidyl esters may be obtained by using plant oil or a plant oil fractions having a maximum level of 3 weight-% diacylglycerols (DAG) in the oil refinement process.

  本发明通常涉及石油精炼领域。特别地，本发明涉及用于生产精制油的工艺领域，这些油基本上不含有污染物，例如环氧丙酯酯类。根据本发明，通过在油精炼过程中使用最大含量为3重量-%的二酰基甘油酯（DAG）的植物油或植物油部分，可以获得不含环氧丙酯酯类的精制植物油。