2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide | 1290088-93-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide
• 英文别名: N-benzyl-2-[(3Z)-3-[(4-fluoroanilino)-phenylmethylidene]-2-oxoindol-1-yl]-4-methylpentanamide
• CAS: 1290088-93-5
• 化学式: C₃₄H₃₂FN₃O₂
• 分子量: 533.645
• InChiKey: VIVLEECSHXKWID-MVJHLKBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.88
• 重原子数：
  40.0
• 可旋转键数：
  9.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  61.44
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  异戊醛 在 palladium diacetate 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 31.75h， 生成 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide
  参考文献：
  名称：

  Palladium catalyzed stereoselective synthesis of 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues

  摘要：

  Potentially bioactive 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues have been synthesized via a two-step procedure: (a) an Ugi-4MCR and (b) reaction of the Ugi adduct with aniline in the presence of a palladium catalyst via domino Heck/Buchwald reaction. In all cases, a single isomer with the Z-configuration was obtained in good to high yields. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.02.005

文献信息

• Palladium catalyzed stereoselective synthesis of 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues
  作者：Morteza Bararjanian、Saeedeh Hosseinzadeh、Saeed Balalaie、Hamid Reza Bijanzadeh

  DOI：10.1016/j.tet.2011.02.005

  日期：2011.4

  Potentially bioactive 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues have been synthesized via a two-step procedure: (a) an Ugi-4MCR and (b) reaction of the Ugi adduct with aniline in the presence of a palladium catalyst via domino Heck/Buchwald reaction. In all cases, a single isomer with the Z-configuration was obtained in good to high yields. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.