6-bromo-2,3-dimethyl-4-phenylsulfonylamidophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-bromo-2,3-dimethyl-4-phenylsulfonylamidophenol
• 英文别名: N-(5-bromo-4-hydroxy-2,3-dimethylphenyl)benzenesulfonamide
• 化学式: C₁₄H₁₄BrNO₃S
• 分子量: 356.24
• InChiKey: OEBXGIWQVPVBJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-bromo-2,3-dimethyl-4-phenylsulfonylamidophenol 在 lead(IV) acetate 作用下， 以67%的产率得到6-bromo-2,3-dimethyl-N-phenylsulfonyl-1,4-benzoquinone monoimine
  参考文献：
  名称：

  Halogenation of N-substituted para-quinone monoimine and para-quinone monooxime esters: VI. Regular trends in chlorination and bromination of N-arylsulfonyl-1,4-benzoquinone monoimines alkyl-substituted in the quinoid ring

  摘要：

  Reactions of halogens with N-arylsulfonyl- 1,4-benzoquinone monoimines occur with the formation of a halogenonium ion that either transforms into a carbocation where the first halogen atom adds to the carbon in the ortho-position relative to the carbonyl carbon, or the halogenonium ion adds directly the second halogen atom.

  DOI：

  10.1134/s107042800605006x
• 作为产物：
  描述：

  N-(4-hydroxy-2,3-dimethylphenyl)benzenesulfonamide 在 溴 作用下， 以 氯仿 为溶剂， 以90%的产率得到6-bromo-2,3-dimethyl-4-phenylsulfonylamidophenol
  参考文献：
  名称：

  Halogenation of N-substituted para-quinone monoimine and para-quinone monooxime esters: VI. Regular trends in chlorination and bromination of N-arylsulfonyl-1,4-benzoquinone monoimines alkyl-substituted in the quinoid ring

  摘要：

  Reactions of halogens with N-arylsulfonyl- 1,4-benzoquinone monoimines occur with the formation of a halogenonium ion that either transforms into a carbocation where the first halogen atom adds to the carbon in the ortho-position relative to the carbonyl carbon, or the halogenonium ion adds directly the second halogen atom.

  DOI：

  10.1134/s107042800605006x

文献信息

• Halogenation of N-substituted para-quinone monoimine and para-quinone monooxime esters: VI. Regular trends in chlorination and bromination of N-arylsulfonyl-1,4-benzoquinone monoimines alkyl-substituted in the quinoid ring
  作者：A. P. Avdeenko、S. A. Konovalova、O. N. Ludchenko

  DOI：10.1134/s107042800605006x

  日期：2006.5

  Reactions of halogens with N-arylsulfonyl- 1,4-benzoquinone monoimines occur with the formation of a halogenonium ion that either transforms into a carbocation where the first halogen atom adds to the carbon in the ortho-position relative to the carbonyl carbon, or the halogenonium ion adds directly the second halogen atom.