1,4-Didecylpiperazine-2,3-dione | 156909-31-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4-Didecylpiperazine-2,3-dione
• CAS: 156909-31-8
• 化学式: C₂₄H₄₆N₂O₂
• 分子量: 394.641
• InChiKey: LWNMRECRIWOFPO-UHFFFAOYSA-N

物化性质

• 沸点：
  485.2±28.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-Didecylpiperazine-2,3-dione 以65%的产率得到
  参考文献：
  名称：

  Mueller-Westerhoff Ulrich T., Zhou Ming, J. Org. Chem, 59 (1994) N 17, S 4988-4992

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氨基癸烷 以 乙醚 、 乙醇 为溶剂， 反应 12.0h， 生成 1,4-Didecylpiperazine-2,3-dione
  参考文献：
  名称：

  Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones

  摘要：

  The reaction of an equimolar mixture of N,N'-dialkylethylenediamines and diethyl oxalate in diethyl ether or 2-propanol leads to 1,4-dialkylpiperazine-2,3-diones. As cyclic and nearly planar tetraalkyl oxamides, these compounds are able to react with 2 equiv of organolithium or Grignard compounds to form, after hydrolysis, symmetrically substituted alpha-diones in excellent yields. The sequential addition of 1 equiv each of two different organolithium compounds affords unsymmetrically substitute alpha-diones when the more soluble longer chain dialkyl derivatives of piperazine-2,3-dione are employed. The dialkylethylenediamines can conveniently be recovered and recycled to the 1,4-dialkylpiperazine-2,3-diones in good yields.

  DOI：

  10.1021/jo00096a049

文献信息

• Mueller-Westerhoff Ulrich T., Zhou Ming, J. Org. Chem, 59 (1994) N 17, S 4988-4992
  作者：Mueller-Westerhoff Ulrich T., Zhou Ming

  DOI：——

  日期：——
• Synthesis of Symmetrically and Unsymmetrically Substituted .alpha.-Diones from Organometallic Reagents and 1,4-Dialkylpiperazine-2,3-diones
  作者：Ulrich T. Mueller-Westerhoff、Ming Zhou

  DOI：10.1021/jo00096a049

  日期：1994.8

  The reaction of an equimolar mixture of N,N'-dialkylethylenediamines and diethyl oxalate in diethyl ether or 2-propanol leads to 1,4-dialkylpiperazine-2,3-diones. As cyclic and nearly planar tetraalkyl oxamides, these compounds are able to react with 2 equiv of organolithium or Grignard compounds to form, after hydrolysis, symmetrically substituted alpha-diones in excellent yields. The sequential addition of 1 equiv each of two different organolithium compounds affords unsymmetrically substitute alpha-diones when the more soluble longer chain dialkyl derivatives of piperazine-2,3-dione are employed. The dialkylethylenediamines can conveniently be recovered and recycled to the 1,4-dialkylpiperazine-2,3-diones in good yields.