N-Orotylglycin | 16296-40-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Orotylglycin
• 英文别名: Orotylglycine；N-(2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-glycine；2-[(2,6-dihydroxypyrimidine-4-carbonyl)amino]acetic acid
• CAS: 16296-40-5
• 化学式: C₇H₇N₃O₅
• mdl: MFCD01096165
• 分子量: 213.15
• InChiKey: KXUHDDGHQOKAAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甘氨酸乙酯盐酸盐 、 乳清酸 、 三氯氧磷 以36%的产率得到
  参考文献：
  名称：

  KUCHINSKAYA, T. A.;NOVICHKOVA, A. S.;IZMOZHEROV, N. A.;POGORELOV, A. S., XIMIYA ORGAN. SOEDIN. AZOTA, PERM, 1981, 110-114

  摘要：

  DOI：

文献信息

• Melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promotor and wrinkle ameliorant
  申请人：SHOWA DENKO K.K.

  公开号：US10646487B2

  公开（公告）日：2020-05-12

  The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring].

  本发明提供了一种含有芦荟酸衍生物的制剂，该制剂在溶剂中的溶解度高，并具有优异的生理活性。本发明的制剂是一种黑色素生成抑制剂、美白剂、成纤维细胞激活剂、胶原蛋白和/或弹性蛋白生成促进剂或皱纹改善剂，其活性成分含有由下式通式（1）代表的橙花酸衍生物或其盐。在式 (1) 中，R 最好代表谷氨酸、甘氨酸、组氨酸或天冬氨酸的侧链。[在式 (1) 中，R 代表天然存在的氨基酸的侧链，R 可与通过单个碳原子与其相邻的氮原子一起形成杂环]。
• MELANIN PRODUCTION INHIBITOR, WHITENING AGENT, FIBROBLAST ACTIVATOR, COLLAGEN AND/OR ELASTIN PRODUCTION PROMOTER AND WRINKLE AMELIORANT
  申请人：SHOWA DENKO K.K.

  公开号：US20190224199A1

  公开（公告）日：2019-07-25

  The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]
• MELANIN PRODUCTION INHIBITOR, WHITENING AGENT, FIBROBLAST ACTIVATOR, COLLAGEN AND/OR ELASTIN PRODUCTION PROMOTOR AND WRINKLE AMELIORANT
  申请人：SHOWA DENKO K.K.

  公开号：US20200215069A1

  公开（公告）日：2020-07-09

  The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]