8-cyclohexyl-3-methyl-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazol-3-ium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-cyclohexyl-3-methyl-5,6-dihydro-4H-pyrazino[3,2,1-jk]carbazol-3-ium
• 英文别名: 12-cyclohexyl-4-methyl-1-aza-4-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-2,4,9(16),10(15),11,13-hexaene
• 化学式: C21H25N2+
• 分子量: 305.4
• InChiKey: QQSYMWNHDZOJQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  8.3
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• DEATH RECEPTOR SENSITIZING COMPOUNDS AND METHODS OF USE THEREFOR
  申请人：Schimmer Aaron D.

  公开号：US20080166378A1

  公开（公告）日：2008-07-10

  Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
• Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
  申请人：Reed John C.

  公开号：US20080206287A1

  公开（公告）日：2008-08-28

  Cyclosporin A has been discovered to sensitize cancers resistant to TNF-family death receptors such as TRAIL and Fas to ligand-mediated apoptosis. Therefore, compositions that include cyclosporin A are useful in treating such cancers.
• US8008354B2
  申请人：——

  公开号：US8008354B2

  公开（公告）日：2011-08-30
• [EN] USE OF CYCLOSPORIN A TO SENSITIZE RESISTANT CANCER CELLS TO DEATH RECEPTOR LIGANDS<br/>[FR] UTILISATION DE CYCLOSPORINE A POUR SENSIBILISER DES CELLULES CANCÉREUSES RÉSISTANTES À DES LIGANDS DE RÉCEPTEUR DE MORT
  申请人：BURHAM INST FOR MEDICAL RES

  公开号：WO2008036244A1

  公开（公告）日：2008-03-27

  [EN] Cyclosporin A has been discovered to sensitize cancers resistant to TNF-family death receptors such as TRAIL and Fas to ligand-mediated apoptosis. Therefore, compositions that include cyclosporin A are useful in treating such cancers.
  [FR] Des recherches ont montré que la cyclosporine A sensibilise les cancers résistants aux récepteurs de mort de la famille du TNF, de type TRAIL et Fas à l'apoptose dont la médiation est assurée par des ligands. L'invention propose ainsi des compositions qui comprennent de la cyclosporine A utiles dans le traitement desdits cancers.