benzyl N-[6-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-6-oxohexyl]carbamate | 869531-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl N-[6-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-6-oxohexyl]carbamate
• CAS: 869531-55-5
• 化学式: C₂₂H₂₈F₆N₄O₅
• 分子量: 542.479
• InChiKey: GYODWIDBZIMKSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  37
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  benzyl N-[6-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-6-oxohexyl]carbamate 在 水 、 sodium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 56.0h， 生成
  参考文献：
  名称：

  Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake

  摘要：

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.

  DOI：

  10.1021/ol051496y
• 作为产物：
  描述：

  N-苄氧羰基--6-氨基己酸 在 N-甲基吗啉 作用下， 以 乙腈 为溶剂， 反应 17.5h， 生成 benzyl N-[6-[bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]-6-oxohexyl]carbamate
  参考文献：
  名称：

  Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake

  摘要：

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.

  DOI：

  10.1021/ol051496y

文献信息

• Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake
  作者：Paul A. Wender、Erik Kreider、Erin T. Pelkey、Jonathan Rothbard、Christopher L. VanDeusen

  DOI：10.1021/ol051496y

  日期：2005.10.1

  [GRAPHICS]Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.