N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-[2-(6-chloropyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl]-L-phenylalanine | 1031341-84-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-[2-(6-chloropyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl]-L-phenylalanine
• 英文别名: (S)-2-(2-Bromo-3-oxo-spiro[3.5]non-1-en-1-ylamino)-3-{4-[2-(6-chloro-pyridin-3-yl)-imidazo[4,5-b]pyridin-3-yl]-phenyl}-propionic acid；(2S)-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-[4-[2-(6-chloropyridin-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl]propanoic acid
• CAS: 1031341-84-0
• 化学式: C₂₉H₂₅BrClN₅O₃
• 分子量: 606.906
• InChiKey: WEBZMJPCAJJKTN-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-[2-(6-chloropyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl]-L-phenylalanine 、 二甲胺 以 甲醇 为溶剂， 反应 2.5h， 以95%的产率得到N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-{2-[6-(dimethylamino)pyridin-3-yl]-3H-imidazo[4,5-b]pyridin-3-yl}-L-phenylalanine
  参考文献：
  名称：

  WO2008/64830

  摘要：

  公开号：
• 作为产物：
  描述：

  ethyl N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-[2-(6-chloropyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl]-L-phenylalaninate 在 sodium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 生成 N-(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)-4-[2-(6-chloropyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl]-L-phenylalanine
  参考文献：
  名称：

  Imidazopyridines as VLA-4 integrin antagonists

  摘要：

  We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.075

文献信息

• [EN] BICYCLIC AND HETEROBICYCLIC DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR PHARMACEUTICAL USES<br/>[FR] DÉRIVÉS BICYCLIQUES ET HÉTÉROBICYCLIQUES, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：UCB PHARMA SA

  公开号：WO2008064830A1

  公开（公告）日：2008-06-05

  [EN] The present invention concerns bicyclic and heterobicyclic derivatives of formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
  [FR] La présente invention concerne des dérivés bicycliques et hétérobicycliques de formule I, leurs procédés de fabrication, des compositions pharmaceutiques les contenant et leur utilisation comme produits pharmaceutiques.
• WO2008/64830
  申请人：——

  公开号：——

  公开（公告）日：——
• Imidazopyridines as VLA-4 integrin antagonists
  作者：David J. Phillips、Richard J. Davenport、Thierry A. Demaude、Fiona P. Galleway、Mark W. Jones、Laurent Knerr、Benjamin G. Perry、Andrew J. Ratcliffe

  DOI：10.1016/j.bmcl.2008.05.075

  日期：2008.7

  We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure-activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule. (c) 2008 Elsevier Ltd. All rights reserved.