methyl 4-cyclopropyl-2-methyl-4-oxobutanoate | 130574-72-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: methyl 4-cyclopropyl-2-methyl-4-oxobutanoate
• CAS: 130574-72-0
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: QJTXVYBNUXSLDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 1α-methoxy-2β-methyl-<1,1'-bicylopropyl>-2α-carboxylate 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以88%的产率得到methyl 4-cyclopropyl-2-methyl-4-oxobutanoate
  参考文献：
  名称：

  Synthesis of bicyclopropyl derivatives from the reaction of cyclopropylcarbene-chromium complexes with alkenes

  摘要：

  The reaction of cyclopropylcarbene-chromium complexes with alkenes has been examined. The reaction leads to cyclopropylcyclopropane derivatives in good yield, accompanied by minor amounts of ring-opened products. Conjugated dienes and alpha,beta-unsaturated esters and amides appear to be suitable substrates for the reaction. The products of the reaction are donor-acceptor substituted cyclopropanes and are further susceptible to transformations typical of this class of compounds.

  DOI：

  10.1021/jo00001a055

文献信息

• HERNDON, JAMES W.;TUMER, SENIZ U., J. ORG. CHEM., 56,(1991) N, C. 286-294
  作者：HERNDON, JAMES W.、TUMER, SENIZ U.

  DOI：——

  日期：——
• Synthesis of bicyclopropyl derivatives from the reaction of cyclopropylcarbene-chromium complexes with alkenes
  作者：James W. Herndon、Seniz U. Tumer

  DOI：10.1021/jo00001a055

  日期：1991.1

  The reaction of cyclopropylcarbene-chromium complexes with alkenes has been examined. The reaction leads to cyclopropylcyclopropane derivatives in good yield, accompanied by minor amounts of ring-opened products. Conjugated dienes and alpha,beta-unsaturated esters and amides appear to be suitable substrates for the reaction. The products of the reaction are donor-acceptor substituted cyclopropanes and are further susceptible to transformations typical of this class of compounds.