Methyl 9-(trimethylsilyl)nona-2,8-diynoate | 144534-41-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 9-(trimethylsilyl)nona-2,8-diynoate
• 英文别名: Methyl 9-trimethylsilylnona-2,8-diynoate
• CAS: 144534-41-8
• 化学式: C₁₃H₂₀O₂Si
• 分子量: 236.386
• InChiKey: JRWIQCYQUGRSIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-丙炔-1-醇 、 Methyl 9-(trimethylsilyl)nona-2,8-diynoate 在 四(三苯基膦)镍 作用下， 生成 5-Hydroxymethyl-7-(6-trimethylsilylhex-5-ynyl)-3H-benzofuran-1-one 、 Methyl 3,5-bis(hydroxymethyl)-2-(6-trimethylsilylhex-5-ynyl)benzoate
  参考文献：
  名称：

  Nickel(0)-promoted synthesis of tetralin lactones from the co-cyclisation of monoynes and octa-1,7-diynes terminally substituted with ester or amide groups

  摘要：

  The co-cyclisation of octa-1,7-diynes with a variety of monoynes mediated by nickel(0) requires ester or amide groups at the terminal positions of the diyne and is subject to steric hindrance about the diyne rather than the monoyne; fused tetralin lactones are the most common products obtained in moderate to good yields. Intramolecular cyclisation of two triynes to the same type of product gives superior yields.

  DOI：

  10.1039/p19920002163
• 作为产物：
  描述：

  1-(trimethylsilyl)-1,7-octadiyne 、 氯甲酸甲酯 在 正丁基锂 作用下， 生成 Methyl 9-(trimethylsilyl)nona-2,8-diynoate
  参考文献：
  名称：

  Nickel(0)-promoted synthesis of tetralin lactones from the co-cyclisation of monoynes and octa-1,7-diynes terminally substituted with ester or amide groups

  摘要：

  The co-cyclisation of octa-1,7-diynes with a variety of monoynes mediated by nickel(0) requires ester or amide groups at the terminal positions of the diyne and is subject to steric hindrance about the diyne rather than the monoyne; fused tetralin lactones are the most common products obtained in moderate to good yields. Intramolecular cyclisation of two triynes to the same type of product gives superior yields.

  DOI：

  10.1039/p19920002163

文献信息

• Nickel(0)-promoted synthesis of tetralin lactones from the co-cyclisation of monoynes and octa-1,7-diynes terminally substituted with ester or amide groups
  作者：Parveen Bhatarah、Edward H. Smith

  DOI：10.1039/p19920002163

  日期：——

  The co-cyclisation of octa-1,7-diynes with a variety of monoynes mediated by nickel(0) requires ester or amide groups at the terminal positions of the diyne and is subject to steric hindrance about the diyne rather than the monoyne; fused tetralin lactones are the most common products obtained in moderate to good yields. Intramolecular cyclisation of two triynes to the same type of product gives superior yields.