Palmityl palmitoleate | 22393-83-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Palmityl palmitoleate
• 英文别名: hexadecyl (Z)-hexadec-9-enoate
• CAS: 22393-83-5
• 化学式: C₃₂H₆₂O₂
• 分子量: 478.8
• InChiKey: YEHRXIRYXGNEDS-PEZBUJJGSA-N

物化性质

• 保留指数：
  3328.75

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  34
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  palmitoleoyl-CoA(4-) 、 1-十六烷醇 生成 Palmityl palmitoleate 、 coenzyme A
  参考文献：
  名称：

  Identification of Two Novel Human Acyl-CoA Wax Alcohol Acyltransferases

  摘要：

  The esterification of alcohols such as sterols, diacylglycerols, and monoacylglycerols with fatty acids represents the formation of both storage and cytoprotective molecules. Conversely, the overproduction of these molecules is associated with several disease pathologies, including atherosclerosis and obesity. The human acyl-CoA:diacylglycerol acyltransferase (DGAT) 2 gene superfamily comprises seven members, four of which have been previously implicated in the synthesis of di- or triacylglycerol. The remaining 3 members comprise an X-linked locus and have not been characterized. We describe here the expression of DGAT2 and the three X-linked genes in Saccharomyces cerevisiae strains virtually devoid of neutral lipids. All four gene products mediate the synthesis of triacylglycerol; however, two of the X-linked genes act as acyl-CoA wax alcohol acyltransferases (AWAT 1 and 2) that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. AWAT1 and AWAT2 have very distinct substrate preferences in terms of alcohol chain length and fatty acyl saturation. The enzymes are expressed in many human tissues but predominate in skin. In situ hybridizations demonstrate a differentiation-specific expression pattern within the human sebaceous gland for the two AWAT genes, consistent with a significant role in the composition of sebum.

  DOI：

  10.1074/jbc.m500025200

文献信息

• Anti-inflammatory creatine composition comprising a cetylated fatty acid
  申请人：Golini, Jeffrey M.

  公开号：EP2283836A1

  公开（公告）日：2011-02-16

  An anti-inflammatory composition for treatment of inflamed joints. This composition includes an alkali buffered creatine and a cetylated fatty acid. The composition can be used for treating inflammation either by oral ingestion or by topical treatment.

  一种用于治疗关节发炎的消炎组合物。 该组合物包括碱缓冲肌酸和十六烷基化脂肪酸。 该组合物可通过口服或局部治疗用于治疗炎症。
• Fungal cells and methods for production of very long chain fatty acid derived products
  申请人：BIOPETROLIA AB

  公开号：US10550413B2

  公开（公告）日：2020-02-04

  The present invention generally relates to a genetically modified fungal cell capable of producing a very long, chain fatty acid (VLCFA) and/or a VLCFA derivative. The genetically modified fungal cell comprises at least one exogenous gene encoding a fatty acyl-CoA reductase, and at least one gene encoding an elongase, and/or at least one gene encoding a fatty acid synthase.

  本发明一般涉及一种能够生产超长链脂肪酸（VLCFA）和/或 VLCFA 衍生物的转基因真菌细胞。转基因真菌细胞包括至少一个编码脂肪酰-CoA 还原酶的外源基因、至少一个编码伸长酶的基因和/或至少一个编码脂肪酸合成酶的基因。
• Composition
  申请人：Moloney Peter Anthony

  公开号：US20050255166A1

  公开（公告）日：2005-11-17

  A therapeutic composition is described comprising honey or a honey derivative, a surfactant, and at least one topical carrier or vehicle selected from the group consisting of a fatty ester, a wax and a wax-like compound; wherein the composition has been subjected to a sterilisation effective dosage of radiation, and wherein the topical carrier or vehicle, when subjected to that dosage, does not substantially modify the properties of the composition present before the sterilisation.

  描述了一种治疗组合物，该组合物由蜂蜜或蜂蜜衍生物、表面活性剂和至少一种局部载体或载体组成，该局部载体或载体选自由脂肪酯、蜡和蜡状化合物组成的组。
• METHODS OF DELIVERY OF CETYL MYRISTOLEATE
  申请人：CG and Associates

  公开号：EP1171115A1

  公开（公告）日：2002-01-16
• FUNGAL CELLS AND METHODS FOR PRODUCTION OF VERY LONG CHAIN FATTY ACID DERIVED PRODUCTS
  申请人：Biopetrolia AB

  公开号：EP3277827A1

  公开（公告）日：2018-02-07