5-(2,3,5,6-tetrafluoro-4-morpholinophenyl)-1,2,4-oxadiazole-3-carboxamide | 1370025-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 5-(2,3,5,6-tetrafluoro-4-morpholinophenyl)-1,2,4-oxadiazole-3-carboxamide
• 英文别名: 5-(2,3,5,6-Tetrafluoro-4-morpholin-4-ylphenyl)-1,2,4-oxadiazole-3-carboxamide
• CAS: 1370025-86-7
• 化学式: C₁₃H₁₀F₄N₄O₃
• 分子量: 346.241
• InChiKey: ZKHIRMOMOSLZQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  O-pentafluorobenzoylcarboxyethylamidoxime 在 氨 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 73.0h， 生成 5-(2,3,5,6-tetrafluoro-4-morpholinophenyl)-1,2,4-oxadiazole-3-carboxamide
  参考文献：
  名称：

  Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives

  摘要：

  In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone as reference drugs. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.02.002

文献信息

• Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives
  作者：Antonio Palumbo Piccionello、Rosario Musumeci、Clementina Cocuzza、Cosimo Gianluca Fortuna、Annalisa Guarcello、Paola Pierro、Andrea Pace

  DOI：10.1016/j.ejmech.2012.02.002

  日期：2012.4

  In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone as reference drugs. (C) 2012 Elsevier Masson SAS. All rights reserved.