2-(p-Nitrophenyl)-4-tert-butylmorpholin. | 70548-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(p-Nitrophenyl)-4-tert-butylmorpholin.
• 英文别名: 4-tert-butyl-2-(4-nitro-phenyl)-morpholine；4-Tert-butyl-2-(4-nitrophenyl)morpholine
• CAS: 70548-03-7
• 化学式: C₁₄H₂₀N₂O₃
• 分子量: 264.324
• InChiKey: XGRWJOXQAYLPNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(tert-butylamino)-1-(4-nitrophenyl)ethanol 、 2-氯乙醇 生成 2-(p-Nitrophenyl)-4-tert-butylmorpholin.
  参考文献：
  名称：

  Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines

  摘要：

  A series of 1-(p-nitrophenyl)-2-aminoethanol derivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl-substituted compounds. In agreement with the previously obtained results, the weak alpha-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of alpha-adrenergic drugs.

  DOI：

  10.1021/jm00192a023

文献信息

• BALSAMO A.; CROTTI P.; LAPUCCI A.; MACCHIA B.; MACCHIA F.; TACCA M. DEL; +, J. MED. CHEM., 1979, 22, NO 6, 738-741
  作者：BALSAMO A.、 CROTTI P.、 LAPUCCI A.、 MACCHIA B.、 MACCHIA F.、 TACCA M. DEL、 +

  DOI：——

  日期：——
• Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines
  作者：A. Balsamo、P. Crotti、A. Lapucci、B. Macchia、F. Macchia、M. Del Tacca、L. Mazzanti、R. Ceserani

  DOI：10.1021/jm00192a023

  日期：1979.6

  A series of 1-(p-nitrophenyl)-2-aminoethanol derivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl-substituted compounds. In agreement with the previously obtained results, the weak alpha-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of alpha-adrenergic drugs.