2-(tert-butylamino)-1-(4-nitrophenyl)ethanol | 15235-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(tert-butylamino)-1-(4-nitrophenyl)ethanol
• 英文别名: 2-tert.Butylamino-1-<4-nitro-phenyl>-aethan-1-ol；α-[(tert-butylamino)methyl]-p-nitrobenzyl alcohol；2-Tert-butylamino-1-(4-nitro-phenyl)-ethanol
• CAS: 15235-97-9
• 化学式: C₁₂H₁₈N₂O₃
• 分子量: 238.287
• InChiKey: SBUQQKAXTBKUJG-UHFFFAOYSA-N

物化性质

• 熔点：
  125 °C
• 沸点：
  382.9±32.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(tert-butylamino)-1-(4-nitrophenyl)ethanol 、 2-氯乙醇 生成 2-(p-Nitrophenyl)-4-tert-butylmorpholin.
  参考文献：
  名称：

  Conformational effects on the activity of drugs. 7. Synthesis and pharmacological properties of 2-(p-nitrophenyl)-substituted morpholines

  摘要：

  A series of 1-(p-nitrophenyl)-2-aminoethanol derivatives and their morpholine analogues have been synthesized and pharmacologically investigated in order to confirm some pharmacological observations made with the N-isopropyl-substituted compounds. In agreement with the previously obtained results, the weak alpha-adrenergic-stimulating activity and the potentiating effect on the responses to norepinephrine found in the open-chain compounds persist in their corresponding semirigid cyclic analogues. The results are discussed in the light of common knowledge of the structure-activity relationships of alpha-adrenergic drugs.

  DOI：

  10.1021/jm00192a023

文献信息

• Phenylethanolamine derivatives and acid addition salts thereof for the
  申请人：American Cyanamid Company

  公开号：US04407819A1

  公开（公告）日：1983-10-04

  There is provided a method for increasing lean meat deposition and/or improving lean meat to fat ratio in poultry, domestic pets, sheep, swine, rabbits, goats and cattle by administering, orally or parenterally, to said animals an effective amount of a phenylethane derivative or acid salt thereof.

  提供了一种方法，通过向家禽、家畜、绵羊、猪、兔、山羊和牛口服或静脉注射苯乙烷衍生物或其酸盐的有效量，以增加瘦肉沉积和/或改善瘦肉与脂肪比例。
• Phenylethanolamine derivatives and acid addition salts thereof for
  申请人：American Cyanamid Company

  公开号：US04404222A1

  公开（公告）日：1983-09-13

  There is provided a method for enhancing the growth rate of meat-producing animals and/or improving the efficiency of feed utilization thereby, which involves, orally or parenterally, administering to said animals a growth-enhancing amount of a phenylethane compound or the acid addition salt thereof.

  提供了一种增强肉类生产动物的生长速度和/或提高饲料利用效率的方法，涉及口服或注射给这些动物一定量的苯乙烷化合物或其酸盐。
• Phenylethane derivatives and acid addition salts thereof for increasing
  申请人：American Cyanamid Company

  公开号：US04522822A1

  公开（公告）日：1985-06-11

  There is provided a method for increasing lean meat deposition and/or improving lean meat to fat ratio in poultry, domestic pets, sheep, swine, rabbits, goats and cattle by administering, orally or parenterally, to said animals an effective amount of a phenylethane derivative or acid salt thereof.

  提供了一种方法，通过给家禽、家养宠物、绵羊、猪、兔、山羊和牛口服或注射苯乙烷衍生物或其酸盐的有效量，来增加瘦肉沉积和/或改善瘦肉与脂肪的比例。
• Method for enhancing the growth rate of meat-producing animals and for improving the lean meat to fat ratio thereof
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0049728A2

  公开（公告）日：1982-04-21

  There is provided a method for enhancing the growth rate of meat-producing animals, improving the efficiency of feed utilization thereby, and or improving the lean meat to fat ratio thereof, which involves, orally or parenterally, administering to said animals a growth-enhancing amount of a phenylethane compound or the acid addition salt thereof.

  提供了一种提高产肉动物生长速度、提高饲料利用效率或改善瘦肉与脂肪比例的方法，该方法包括口服或肠外给所述动物服用一定量的苯乙烷化合物或其酸加成盐，以促进生长。
• Process for preparing 2-hydroxy-2-phenylethylamines
  申请人：ELI LILLY AND COMPANY

  公开号：EP0104888B1

  公开（公告）日：1986-10-15