(5S)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline | 877463-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5S)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline
• 英文别名: (5S)-5-[(3R)-1,4-dioxaspiro[4.5]decan-3-yl]-3-(phenylmethoxymethyl)-4,5-dihydro-1,2-oxazole
• CAS: 877463-63-3
• 化学式: C₁₉H₂₅NO₄
• 分子量: 331.412
• InChiKey: SEMFOZFSHCBIAN-ZWKOTPCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  49.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (5S)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline 在 溶剂黄146 作用下， 以 水 为溶剂， 以92%的产率得到(5S)-5-[(1R)-1,2-dihydroxyethyl]-3-benzyloxymethyl-4,5-dihydrooxazole
  参考文献：
  名称：

  Synthesis of New Nitrogen Analogues of Salacinol and Deoxynojirimycin and Their Evaluation as Glycosidase Inhibitors

  摘要：

  The synthesis of two enantiomerically pure iminosugars, analogues of 1-L-deoxynojirimycin (L-DNJ) and 1-D-deoxymannojirimycin (DW), was achieved using cyclic sulfate substituted isoxazoline derivatives. The piperidine ring was formed via the reduction of an isoxazoline into an amine which underwent a spontaneous intramolecular cyclization by reaction with the cyclic sulfate moiety. The nucleophilic attack of these two trisubstituted piperidines and morpholine on L- and D-erythritol- 1,3-cyclic sulfates gave six new nitrogen analogues of salacinol. The inhibitory properties of the synthesized salacinol analogues were evaluated on several commercial glycosidases.

  DOI：

  10.1021/jo0517388
• 作为产物：
  描述：

  1-benzyloxy-2-nitroethane 、 (2S)-1,2-O-cyclohexylidenebut-3-ene-1,2-diol 在 对苯二异氰酸酯 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 42.0h， 以52%的产率得到(5S)-3-benzyloxymethyl-5-[(1R)-1,2-O-cyclohexylidene-1,2-dihydroxyethyl]-2-isoxazoline
  参考文献：
  名称：

  Synthesis of New Nitrogen Analogues of Salacinol and Deoxynojirimycin and Their Evaluation as Glycosidase Inhibitors

  摘要：

  The synthesis of two enantiomerically pure iminosugars, analogues of 1-L-deoxynojirimycin (L-DNJ) and 1-D-deoxymannojirimycin (DW), was achieved using cyclic sulfate substituted isoxazoline derivatives. The piperidine ring was formed via the reduction of an isoxazoline into an amine which underwent a spontaneous intramolecular cyclization by reaction with the cyclic sulfate moiety. The nucleophilic attack of these two trisubstituted piperidines and morpholine on L- and D-erythritol- 1,3-cyclic sulfates gave six new nitrogen analogues of salacinol. The inhibitory properties of the synthesized salacinol analogues were evaluated on several commercial glycosidases.

  DOI：

  10.1021/jo0517388

文献信息

• Synthesis of New Nitrogen Analogues of Salacinol and Deoxynojirimycin and Their Evaluation as Glycosidase Inhibitors
  作者：Estelle Gallienne、Thierry Gefflaut、Jean Bolte、Marielle Lemaire

  DOI：10.1021/jo0517388

  日期：2006.2.1

  The synthesis of two enantiomerically pure iminosugars, analogues of 1-L-deoxynojirimycin (L-DNJ) and 1-D-deoxymannojirimycin (DW), was achieved using cyclic sulfate substituted isoxazoline derivatives. The piperidine ring was formed via the reduction of an isoxazoline into an amine which underwent a spontaneous intramolecular cyclization by reaction with the cyclic sulfate moiety. The nucleophilic attack of these two trisubstituted piperidines and morpholine on L- and D-erythritol- 1,3-cyclic sulfates gave six new nitrogen analogues of salacinol. The inhibitory properties of the synthesized salacinol analogues were evaluated on several commercial glycosidases.