1-(p-Methoxyphenyl)-imidazolidin | 65112-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(p-Methoxyphenyl)-imidazolidin
• 英文别名: 1-(4-methoxy-phenyl)-imidazolidine；1-(4-Methoxyphenyl)imidazolidine
• CAS: 65112-28-9
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: FZOOLPPBPYESST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 1-(p-Methoxyphenyl)-imidazolidin 以 乙醇 、 水 为溶剂， 生成 1-(4-Methoxyphenyl)-3-[[3-(4-methoxyphenyl)imidazolidin-1-yl]methyl]imidazolidine
  参考文献：
  名称：

  Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents

  摘要：

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.

  DOI：

  10.1016/j.ejmech.2005.03.010
• 作为产物：
  描述：

  N-(4-甲氧基苯基)乙二胺 在 聚合甲醛 作用下， 以 乙醇 、 水 为溶剂， 生成 1-(p-Methoxyphenyl)-imidazolidin
  参考文献：
  名称：

  Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents

  摘要：

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.

  DOI：

  10.1016/j.ejmech.2005.03.010

文献信息

• 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors
  申请人：Ennis Michael Dalton

  公开号：US20080176857A1

  公开（公告）日：2008-07-24

  Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明揭示了化合物及其药物可接受的盐，其中化合物具有公式I的结构：其中A1、A2、A3、A4、A5、A6、A7、A8、X4、X6、R2、R4、R5和R6如本发明详细描述中所定义。本发明还揭示了相应的药物组合物、治疗方法、合成方法和中间体。
• 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1874780A1

  公开（公告）日：2008-01-09
• [EN] 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS<br/>[FR] COMPOSES 4-PIPERAZINNYTHIENO [2,3-D] PYRIMIDINE UTILISES DES INHIBITEURS D'AGREGATION PLAQUETTAIRE
  申请人：PHARMACIA & UPJOHN CO LLC

  公开号：WO2006100591A1

  公开（公告）日：2006-09-28

  [EN] Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein A¹, A², A³, A⁴, A⁵, A⁶, A⁷, A⁸, X⁴, X⁶, R², R⁴, R⁵, and R⁶ are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
  [FR] L'invention concerne des composés et des sels de ceux-ci acceptables sur le plan pharmaceutique, ces composés possédant une structure de formule (I), dans laquelle A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5 et R6 sont tels que définis dans la description détaillée de l'invention. L'invention concerne également des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse et des intermédiaires.
• Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents
  作者：Isabel Perillo、Evangelina Repetto、María Cristina Caterina、Rosana Massa、Gabriel Gutkind、Alejandra Salerno

  DOI：10.1016/j.ejmech.2005.03.010

  日期：2005.8

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.