1-(4-Methoxyphenyl)-3-[[3-(4-methoxyphenyl)imidazolidin-1-yl]methyl]imidazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(4-Methoxyphenyl)-3-[[3-(4-methoxyphenyl)imidazolidin-1-yl]methyl]imidazolidine
• 化学式: C₂₁H₂₈N₄O₂
• 分子量: 368.479
• InChiKey: MKFDWUIPXPISCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(4-甲氧基苯基)乙二胺 在 聚合甲醛 作用下， 以 乙醇 、 水 为溶剂， 生成 1-(4-Methoxyphenyl)-3-[[3-(4-methoxyphenyl)imidazolidin-1-yl]methyl]imidazolidine
  参考文献：
  名称：

  Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents

  摘要：

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.

  DOI：

  10.1016/j.ejmech.2005.03.010

文献信息

• Synthesis, spectroscopic and biological properties of bis(3-arylimidazolidinyl-1)methanes. A novel family of antimicrobial agents
  作者：Isabel Perillo、Evangelina Repetto、María Cristina Caterina、Rosana Massa、Gabriel Gutkind、Alejandra Salerno

  DOI：10.1016/j.ejmech.2005.03.010

  日期：2005.8

  Synthesis, spectroscopic and biological properties of new bis('3-arylimidazolidinyl-1)methanes are described. These compounds were synthesized by condensation reaction between N-arylethylenediamines and formaldehyde. Chemical structures were confirmed by means of their H-1- and C-13-NMR and mass spectroscopic data. Investigation of in vitro antimicrobial activity was performed using Gram-negative and Gram-positive bacteria as well as antifungal studies against Aspergillus niger and Candida albicans. Minimal inhibitory concentrations of active compounds were determined. (c) 2005 Published by Elsevier SAS.