2-(5-Methoxy-benzocyclobutenyl)-ethanol | 68927-65-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(5-Methoxy-benzocyclobutenyl)-ethanol
• 英文别名: 2-(4-Methoxy-7-bicyclo[4.2.0]octa-1(6),2,4-trienyl)ethanol
• CAS: 68927-65-1
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: UXWAIIQJJKNBIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙醇 、 1-(3-methoxyphenoxy)-3-butene 在 硫酸 作用下， 反应 4.0h， 以18%的产率得到3-ethoxy-4-(3-methoxyphenyl)butan-1-ol
  参考文献：
  名称：

  Intramolecular Photochemical Reactions of Bichromophoric 3-(Alkenyloxy)phenols and 1-(Alkenyloxy)-3-(alkyloxy)benzene Derivatives. Acid-Catalyzed Transformations of the Primary Cycloadducts

  摘要：

  Irradiation of 3-(alkenyloxy)phenols and 1-(alkenyloxy)-3-(alkyloxy)benzene derivatives, at lambda = 254 nm in acidic media, yields benzocyclobutenes, 3-alkylphenols, 3-alkylanisols, and 4-alkyl-1,2-dialkyloxybenzenes depending on the substitution pattern of the aromatic ring and the olefinic side chain. The final products are derived from an intramolecular [2 + 2] photocycloaddition and acidic rearrangements from a common intermediate.

  DOI：

  10.1021/jo970554t

文献信息

• Verrat; Hoffmann; Pete, Synlett, 2000, # 8, p. 1166 - 1168
  作者：Verrat、Hoffmann、Pete

  DOI：——

  日期：——
• Intramolecular Photochemical Reactions of Bichromophoric 3-(Alkenyloxy)phenols and 1-(Alkenyloxy)-3-(alkyloxy)benzene Derivatives. Acid-Catalyzed Transformations of the Primary Cycloadducts
  作者：Norbert Hoffmann、Jean-Pierre Pete

  DOI：10.1021/jo970554t

  日期：1997.10.1

  Irradiation of 3-(alkenyloxy)phenols and 1-(alkenyloxy)-3-(alkyloxy)benzene derivatives, at lambda = 254 nm in acidic media, yields benzocyclobutenes, 3-alkylphenols, 3-alkylanisols, and 4-alkyl-1,2-dialkyloxybenzenes depending on the substitution pattern of the aromatic ring and the olefinic side chain. The final products are derived from an intramolecular [2 + 2] photocycloaddition and acidic rearrangements from a common intermediate.