(L)-3-Isobutyl-2,5-morpholinedione | 128996-90-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (L)-3-Isobutyl-2,5-morpholinedione
• 英文别名: 3-isobutyl-2,5-morpholinedione；3-isobutyl-morpholine-2,5-dione；3-Isobutylmorpholine-2,5-dione；3-(2-methylpropyl)morpholine-2,5-dione
• CAS: 128996-90-7
• 化学式: C₈H₁₃NO₃
• 分子量: 171.196
• InChiKey: XCJJDQSWJHACOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(hydroxyacetyl)leucine ethyl ester 以 四氢呋喃 为溶剂， 生成 (L)-3-Isobutyl-2,5-morpholinedione
  参考文献：
  名称：

  Process for the preparation of 3-, 6-substituted 2,5-morpholinediones

  摘要：

  公开了一种制备3-和/或6-取代的2,5-吗啉二酮的方法。这些吗啉二酮可用作合成依赖肽聚合物和共聚物的前体。

  公开号：

  US05466801A1

文献信息

• A New Photolabile Linker for the Photoactivation of Carboxyl Groups
  作者：K. C. Nicolaou、Brian S. Safina、Nicolas Winssinger

  DOI：10.1055/s-2001-14661

  日期：——

  A new photolabile linker enabling nucleophilic cleavage of a carboxyl functionality upon irradiation with UV light (> 290 nm) was developed. When the photocleavage is carried out in the presence of primary or secondary amines, amides are obtained in high yields and purities, while the intramolecular version of this reaction leads to heterocycles via a cyclorelease mechanism.

  开发了一种新的光敏连接子，可以在紫外光照射下（> 290 nm）使羧基功能团进行亲核裂解。当在一级或二级胺存在下进行光裂解时，可以获得高产率和高纯度的酰胺，而该反应的分子内版本通过循环释放机制生成杂环。
• Bioabsorbable polydepsipeptides, their preparation and use
  申请人：PFIZER INC.

  公开号：EP0322154B1

  公开（公告）日：1995-06-28
• METHOD OF PREPARING A PHYSICALLY CROSS-LINKED, LACTIDE-BASED POLYMER SYSTEM, POLYMER SYSTEM PREPARED BY THE METHOD, AND PROCESS OF MANUFACTURING AN OBJECT FROM THE POLYMER SYSTEM
  申请人：Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH

  公开号：EP3625292A1

  公开（公告）日：2020-03-25
• Multiblock Copolymers with Shape-Memory Properties
  申请人：Kelch Steffen

  公开号：US20100062036A1

  公开（公告）日：2010-03-11

  The invention is directed to a multiblock copolymer with shape memory properties and a synthetic precursor of the multiblock copolymer 1. The multiblock copolymer contains: (i) a poly(depsipeptide) segment with an average molecular weight M W in the range of 1,000 to 20,000 g/mol; and (ii) a poly(ε-caprolactone) segment with an average molecular weight M W in the range of 1,000 to 10,000 g/mol.
• Method of preparing a physically cross-linked, lactide-based polymer system, polymer system prepared by the method, and process of manufacturing an object from the polymer system.
  申请人：Helmholtz-Zentrum Geesthacht Zentrum fuer Material- und Kuestenforschung GmbH

  公开号：US20200216606A1

  公开（公告）日：2020-07-09

  The invention provides a method of preparing a lactide-based, biodegradable (biocompatible), physically cross-linked and highly elastic polymer system. The method comprises the steps of: preparing a melt of a copolymer based on a first comonomer and at least one second comonomer, the first comonomer being selected from L-lactide and D-lactide; and adding a lactide-containing stereocomplex forming agent to the melt, wherein the stereocomplex forming agent is selected such that the resulting polymer system comprises a combination of constitution units derived from L-lactide and constitution units derived from D-lactide forming stereocomplexes.