2-[2-Chloro-2-(2-methylphenyl)ethyl]oxolane | 1046454-46-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-Chloro-2-(2-methylphenyl)ethyl]oxolane
• 英文别名: 2-[2-chloro-2-(2-methylphenyl)ethyl]oxolane
• CAS: 1046454-46-9
• 化学式: C₁₃H₁₇ClO
• 分子量: 224.73
• InChiKey: XUNCBGOYCMBFMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 2-甲基苯乙烯 在 叔丁基过氧化氢 、 RhCl(PPh₃)3 、 四氯化钛 作用下， 反应 5.0h， 以55%的产率得到2-[2-Chloro-2-(2-methylphenyl)ethyl]oxolane
  参考文献：
  名称：

  A coupling reaction between tetrahydrofuran and olefins by Rh-catalyzed/Lewis acid-promoted C–H activation

  摘要：

  A novel coupling reaction between tetrahydrofuran and olefins is discovered, in which the consecutive C-C and C-Cl bond-forming process takes place via Rh-catalyzed/lewis acid-promoted C-H activation. This reaction could be developed into a straightforward and effective method for rapid access to 2-(2-chloro-2-arylethyl)-tetrahydrofuran compounds. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.057

文献信息

• A coupling reaction between tetrahydrofuran and olefins by Rh-catalyzed/Lewis acid-promoted C–H activation
  作者：Ke Cao、Yi-Jun Jiang、Shu-Yu Zhang、Chun-An Fan、Yong-Qiang Tu、Yuan-Jiang Pan

  DOI：10.1016/j.tetlet.2008.05.057

  日期：2008.7

  A novel coupling reaction between tetrahydrofuran and olefins is discovered, in which the consecutive C-C and C-Cl bond-forming process takes place via Rh-catalyzed/lewis acid-promoted C-H activation. This reaction could be developed into a straightforward and effective method for rapid access to 2-(2-chloro-2-arylethyl)-tetrahydrofuran compounds. (c) 2008 Elsevier Ltd. All rights reserved.