6-hydroxy-2,9-dimethyl-decan-5-one | 6838-52-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-hydroxy-2,9-dimethyl-decan-5-one
• 英文别名: Isocapronoin；2.9-Dimethyl-decanol-(6)-on-(5)；6-Hydroxy-2,9-dimethyl-decan-5-on；2,9-dimethyl-6-hydroxy-5-decanone；6-Hydroxy-2,9-dimethyldecan-5-one
• CAS: 6838-52-4
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: BYDYJFXRRJSNMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基戊醛 生成 6-hydroxy-2,9-dimethyl-decan-5-one
  参考文献：
  名称：

  BIOFUEL PRODUCTION

  摘要：

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。

  公开号：

  US20090139134A1

文献信息

• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• METHODS AND COMPOSITIONS FOR PRODUCING CHEMICAL PRODUCTS FROM C. PHYTOFERMENTANS
  申请人：Schmalisch Matthias

  公开号：US20110183382A1

  公开（公告）日：2011-07-28

  This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.

  这项发明提供了通过C. phytofermentans生产化合物的系统和方法。C. phytofermentans被基因工程化，用于水解和发酵碳质生物质以合成具有商业价值的化合物。
• Isolated alcohol dehydrogenase enzymes and uses thereof
  申请人：Bio Architecture Lab, Inc.

  公开号：EP2463374A2

  公开（公告）日：2012-06-13

  Bacterial polynucleotides and polypeptides are provided in which the polypeptides have a dehydrogenase activity, such as an alcohol dehydrogenase (ADH) activity, an uronate, a 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU) ((4S,5S)-4,5 dihydroxy-2,6-dioxohexanoate) hydrogenase activity, a 2-keto-3-deoxy-D-gluconate dehydrogenase activity, a D-mannuronate hydrogenase activity, and/or a D-mannnonate dehydrogenase activity. Methods, enzymes, recombinant microorganism, and microbial systems are also provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided.

  提供了细菌多核苷酸和多肽，其中的多肽具有脱氢酶活性，如醇脱氢酶（ADH）活性、尿酸盐、4-脱氧-L-赤式-5-己糖尿酸盐（DEHU）（（4S、5S）-4,5-二羟基-2,6-二氧代己酸）氢化酶活性、2-酮基-3-脱氧-D-葡萄糖酸脱氢酶活性、D-甘露酸氢化酶活性和/或 D-甘露酸脱氢酶活性。还提供了将多糖（如来自生物质的多糖）转化为合适的单糖或低聚糖，以及将合适的单糖或低聚糖转化为商品化学品（如生物燃料）的方法、酶、重组微生物和微生物系统。还提供了通过本文所述方法生产的商品化学品。
• Rapid pretreatment
  申请人：Sweetwater Energy, Inc.

  公开号：US10844413B2

  公开（公告）日：2020-11-24

  Disclosed herein are methods, systems, and compositions for the pretreatment of biomass within seconds with low inhibitor formation. The pretreatment process is used to convert biomass to a fuel or other useful chemicals by subjecting the feedstock to a rapid retention time under pressure and temperature and/or chemical reactant. The system includes a continuously-operating valve discharge apparatus to discharge pretreated feedstock while maintaining uniform pressure on the pretreatment system.

  本文公开了在几秒钟内对生物质进行预处理且抑制剂形成较少的方法、系统和组合物。预处理过程通过使原料在压力和温度和/或化学反应剂作用下快速停留一段时间，将生物质转化为燃料或其他有用的化学品。该系统包括一个连续操作的阀门排放装置，用于排放经预处理的原料，同时保持预处理系统的压力均匀。
• Engineered microorganisms for production of commodity chemicals and cellular biomass
  申请人：The Regents of the University of California

  公开号：US11332723B2

  公开（公告）日：2022-05-17

  The present disclosure provides methods of producing commodity products, the methods involving culturing a host cell that is genetically modified to produce a uronate dehydrogenase (UDH) that converts a sugar acid to its corresponding 1,5-aldonolactone, that uses NADP+ or NAD+ as a cofactor, and that produces NADPH or NADH, respectively, where the host cell coexpresses an endogenous or a heterologous reductase that utilizes the produced NADPH or NADH to generate the commodity product or a precursor thereof. The present disclosure provides a method of producing downstream products of glycerol and pyruvate in a genetically modified microbial host cell, the method involving culturing a genetically modified microbial host cell of the present disclosure in a culture medium comprising D-galacturonic acid. The present disclosure provides variant UDH polypeptides that utilize NADP+, nucleic acids encoding the variant UDH polypeptides; and host cells genetically modified with the nucleic acids.

  本公开提供了生产商品产品的方法，该方法涉及培养宿主细胞，该宿主细胞经过基因改造，可产生一种尿酸脱氢酶（UDH），该酶可将一种糖酸转化为相应的1,5-醛内酯、该宿主细胞利用 NADP+ 或 NAD+ 作为辅助因子，并分别产生 NADPH 或 NADH，其中宿主细胞共同表达一种内源或异源还原酶，该还原酶利用所产生的 NADPH 或 NADH 生成商品或其前体。本公开提供了一种在转基因微生物宿主细胞中生产甘油和丙酮酸下游产物的方法，该方法涉及在包含D-半乳糖醛酸的培养基中培养本公开的转基因微生物宿主细胞。本公开提供了利用 NADP+ 的变体 UDH 多肽、编码变体 UDH 多肽的核酸以及用该核酸遗传修饰的宿主细胞。