L-leucine hydrobromide | 15474-86-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-leucine hydrobromide
• 英文别名: l-Leucine hydrobromide；(2S)-2-amino-4-methylpentanoic acid;hydrobromide
• CAS: 15474-86-9
• 化学式: BrH*C₆H₁₃NO₂
• 分子量: 212.087
• InChiKey: UCDLNIRIHZUFAA-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.02
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  L-亮氨酸 在 氢溴酸 作用下， 反应 6.0h， 生成 L-leucine hydrobromide
  参考文献：
  名称：

  Experimental and theoretical characterization of semiorganic nonlinear optical material l-leucine hydrobromide

  摘要：

  Semiorganic nonlinear optical material L-leucine hydrobromide (LEHBr) has been synthesized and single crystals were grown by solvent evaporation method at a constant temperature of 35 degrees C. CHN test, FTIR and XRD analysis were performed for identification of the material. Thermal and mechanical stability of the grown crystal were investigated by DTA-TGA analysis and microhardness measurement respectively. Suitability of LEHBr for NLO application was studied by optical transmission study and second harmonic generation (SHG) efficiency measurement. SHG efficiency was found to be 4 times of KDP. First hyperpolarizability, dipole moment and polarizability of LEHBr were calculated at the framework of Hartree-Fock (HF) with 6-311G(d) basis set. First order hyperpolarizability was found to be 3.233 x 10(-33) esu which is 4.9 times of urea. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.materresbull.2013.01.012

文献信息

• Peptides for inhibiting retroviruses
  申请人：——

  公开号：US20030091586A1

  公开（公告）日：2003-05-15

  Peptides derived from shark immunoglobulin preparations are used to prepare compositions, including pharmaceutical compositions, for inhibiting retrovirus replication in susceptible cells. The peptide preparations are useful for inhibiting diseases associated with retroviral infection, such as acquired immunodeficiency syndrome. The peptides also inhibit growth of tumor cells, especially sarcomas and leukemias.

  从鲨鱼免疫球蛋白制剂中提取的多肽可用于制备抑制易感细胞中逆转录病毒复制的组合物，包括药物组合物。肽制剂可用于抑制与逆转录病毒感染有关的疾病，如获得性免疫缺陷综合征。多肽还能抑制肿瘤细胞的生长，尤其是肉瘤和白血病。
• PEPTIDES FOR INHIBITING RETROVIRUSES
  申请人：Howard, Mark E.

  公开号：EP0971726A1

  公开（公告）日：2000-01-19
• EP0971726A4
  申请人：——

  公开号：EP0971726A4

  公开（公告）日：2002-07-24
• [EN] PEPTIDES FOR INHIBITING RETROVIRUSES<br/>[FR] PEPTIDES INHIBANT DES RETROVIRUS
  申请人：HOWARD, Mark, E.

  公开号：WO1998017301A1

  公开（公告）日：1998-04-30

  (EN) Peptides derived from shark immunoglobulin preparations are used to prepare compositions, including pharmaceutical compositions, for inhibiting retrovirus replication in susceptible cells. The peptide preparations are useful for inhibiting diseases associated with retroviral infection, such as acquired immunodeficiency syndrome. The peptides also inhibit growth of tumor cells, especially sarcomas and leukemias.(FR) L'invention porte sur des peptides obtenus à partir de préparations d'immunoglobuline provenant du requin et qui sont utilisés pour préparer des compositions telles que des compositions pharmaceutiques destinées à inhiber la réplication des rétrovirus dans des cellules sensibles. Ces préparations peptidiques sont utiles pour inhiber des maladies associées aux infections rétrovirales telles que le syndrome de l'immunodéficience acquise. Ces peptides inhibent également le développement de cellules tumorales, notamment les sarcomes et les leucémies.