N-lauroylaspartic acid | 57229-73-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-lauroylaspartic acid
• 英文别名: lauroylaspartic acid；N-lauroyl-DL-aspartic acid；N-Lauroyl-DL-asparaginsaeure；n-Dodecanoylaspartic acid；2-(dodecanoylamino)butanedioic acid
• CAS: 57229-73-9
• 化学式: C₁₆H₂₉NO₅
• 分子量: 315.41
• InChiKey: VCRXMSMANOGRCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-lauroyl-DL-aspartic acid-anhydride 在 sodium hydroxide 作用下， 生成 N-lauroylaspartic acid
  参考文献：
  名称：

  The Preparation of Long Chain N-Acylamino Acids

  摘要：

  DOI：

  10.1021/ja01582a049

文献信息

• PREPARATION OF AMINO ACID-FATTY ACID AMIDES
  申请人：Chaudhuri Shan

  公开号：US20080200704A1

  公开（公告）日：2008-08-21

  The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

  本发明描述了由氨基酸分子和脂肪酸分子产生的化合物。这些化合物采用酰胺键结合的氨基脂肪酸化合物的形式存在，或者是由氨基酸或其衍生物与先前与硫酰卤反应的适当脂肪酸反应而成的混合物。这些分子的使用可提供具有增强生物利用度和特定脂肪酸所赋予的额外益处的补充氨基酸。
• Self-assembled prebiotic amphiphile-mixture exhibits tunable catalytic properties
  作者：Raki Mandal、Anupam Ghosh、Nilesh K. Rout、Mahesh Prasad、Bibhas Hazra、Sanu Sar、Subrata Das、Ayan Datta、Pradip K. Tarafdar

  DOI：10.1039/d3ob00606a

  日期：——

  acid : fatty acid mixtures. The histidine-based amphiphiles were able to catalyze hydrolytic reactions at the self-assembled surface (with a rate increase of ∼1000-fold), and the catalytic ability can be tuned by linkage of the fatty carbon part to histidine (N-acylated vs. O-acylated). Moreover, the presence of cationic serine-based amphiphiles on the surface enhances the catalytic efficiency by another ∼2-fold

  通过两亲分子的自组装形成原细胞表面，以及通过简单的肽/原 RNA 进行催化是原细胞进化的两个重要支柱。为了寻找益生元自组装支持的催化反应，我们认为基于氨基酸的两亲物可能发挥重要作用。在本文中，我们研究了在温和的益生元条件下从氨基酸：脂肪醇和氨基酸：脂肪酸混合物中基于组氨酸和丝氨酸的两亲物的形成。基于组氨酸的两亲物能够在自组装表面催化水解反应（速率增加约 1000 倍），并且催化能力可以通过脂肪碳部分与组氨酸的连接来调节（N-酰化与.O _-酰化）。此外，表面上阳离子丝氨酸两亲物的存在将催化效率提高了约2倍，而阴离子天冬氨酸两亲物的存在降低了催化活性。酯分配到表面、反应性和游离脂肪酸的积累解释了催化表面的底物选择性，其中发现己酯比其他脂肪酰基酯更易水解。–NH 2的二甲基化OLH 的催化效率进一步提高了约 2 倍，而三甲基化降低了催化能力。自组装、电荷-电荷排斥和与酯羰基的氢键可能是 O-月
• PROTECTANT FOR ELECTRON MICROSCOPE OBSERVATION OF HYDRATED BIOLOGICAL SAMPLE, KIT FOR ELECTRON MICROSCOPE OBSERVATION, METHOD FOR OBSERVATION, DIAGNOSIS, EVALUATION, OR QUANTIFICATION BY ELECTRON MICROSCOPE, AND SAMPLE STAGE
  申请人：Japan Science and Technology Agency

  公开号：EP3101407A1

  公开（公告）日：2016-12-07

  Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a survival environment imparting component, a saccharide, and an electrolyte.

  本发明提供了一种用于在真空中进行电子显微镜观察的保护剂，它可以保护含水状态下的生物样品，如哺乳动物、植物组织或培养细胞，以及活体状态下的单细胞，即使在真空中也不会使其变形；还提供了一种使用该保护剂的试剂盒、一种用电子显微镜对样品进行观察、诊断、评估和定量的方法，以及一种用于观察的样品台。本发明的用于电子显微镜观察的保护剂含有生存环境赋予成分、糖类和电解质。
• METHOD FOR PRODUCING REFOLDED PROTEIN BY USING FLOW MICROREACTOR, AND PROTEIN REFOLDING APPARATUS
  申请人：AJINOMOTO CO., INC.

  公开号：EP3878856A1

  公开（公告）日：2021-09-15

  The present invention provides a method for producing a refolded protein, the method comprising a step for mixing, inside a micro mixer, a buffer and a solubilization solution for a protein that has lost higher order structure or that has become insoluble.

  本发明提供了一种生产再折叠蛋白质的方法，该方法包括在微型混合器内混合缓冲液和增溶液的步骤，缓冲液用于已失去高阶结构或变得不溶解的蛋白质。
• HYDROPHOBIC ALGINIC ACID PARTICLE GROUP AND METHOD FOR PRODUCING SAME
  申请人：Nisshinbo Holdings Inc.

  公开号：EP3922666A1

  公开（公告）日：2021-12-15

  The present invention provides a hydrophobic alginic acid particle group which is obtained by subjecting a polyvalent metal alginate to a hydrophobization treatment, and which is configured such that the water absorption per 100 g of the particles is lower than the oil absorption per 100 g of the particles.

  本发明提供了一种疏水性海藻酸粒子群，它是通过对多价金属海藻酸盐进行疏水处理而获得的，其配置使得每 100 克粒子的吸水率低于每 100 克粒子的吸油量。