tert-butyl N-[N'-(2-(trimethylsilyl)ethylsulfonyl)-4-aminobut-1-yl]carbamate | 217454-43-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: tert-butyl N-[N'-(2-(trimethylsilyl)ethylsulfonyl)-4-aminobut-1-yl]carbamate
• 英文别名: tert-butyl N-[4-(2-trimethylsilylethylsulfonylamino)butyl]carbamate
• CAS: 217454-43-8
• 化学式: C₁₄H₃₂N₂O₄SSi
• 分子量: 352.571
• InChiKey: FVTXIQNOGWESRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  92.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[N'-(2-(trimethylsilyl)ethylsulfonyl)-4-aminobut-1-yl]carbamate 在 四(三苯基膦)钯 potassium fluoride 、 1,3-二甲基巴比妥酸 、 Celite 、 potassium carbonate 、 三乙胺 、 N,N-二异丙基乙胺 、 sodium iodide 作用下， 以 二氯甲烷 、 乙酸乙酯 、 甲苯 、 乙腈 为溶剂， 反应 151.0h， 生成 tert-butyl N-{16-azido-9-[3-(p-methoxyphenyl)prop-2-enoyl]-13-(2,2,2-trichloro-tert-butoxycarbonyl)-5-(2-(trimethylsilyl)ethylsulfonyl)-5,9,13-triazahexadec-1-yl}carbamate
  参考文献：
  名称：

  Synthesis of Penta-N-Protected Homocaldopentamine and Its Selective Acylation

  摘要：

  The synthesis of the penta-N-protected polyamine homocaldopentamine {PA 4333, 1, tert-butyl N-[9-allyl-16-azido-13-(2,2,2-trichloro-tert-butoxycarbonyl)-5-(trimethylsilylethylsulfonyl)-5,9,13-triazahexadec-1-yl]carbamate}, containing five independent amino-protecting groups is described. These five protecting groups used-allyl, azido, tert-butoxycarbonyl (BOC), 2,2,2-trichloro-tert-butoxycarbonyl (TCBOC), and trimethylsilylethylsulfonyl (SES)-were removed selectively. The acylation with p-methoxycinnamoyl chloride at each nitrogen of the pentaamine was determined.

  DOI：

  10.1021/jo980689e
• 作为产物：
  描述：

  N-叔丁氧羰基-1,4-丁二胺 、 2-(三甲基硅基)乙烷磺酰氯 在 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 7.0h， 以85%的产率得到tert-butyl N-[N'-(2-(trimethylsilyl)ethylsulfonyl)-4-aminobut-1-yl]carbamate
  参考文献：
  名称：

  Synthesis of Penta-N-Protected Homocaldopentamine and Its Selective Acylation

  摘要：

  The synthesis of the penta-N-protected polyamine homocaldopentamine {PA 4333, 1, tert-butyl N-[9-allyl-16-azido-13-(2,2,2-trichloro-tert-butoxycarbonyl)-5-(trimethylsilylethylsulfonyl)-5,9,13-triazahexadec-1-yl]carbamate}, containing five independent amino-protecting groups is described. These five protecting groups used-allyl, azido, tert-butoxycarbonyl (BOC), 2,2,2-trichloro-tert-butoxycarbonyl (TCBOC), and trimethylsilylethylsulfonyl (SES)-were removed selectively. The acylation with p-methoxycinnamoyl chloride at each nitrogen of the pentaamine was determined.

  DOI：

  10.1021/jo980689e

文献信息

• Synthesis of Penta-<i>N</i>-Protected Homocaldopentamine and Its Selective Acylation
  作者：Jae Kyoung Pak、Manfred Hesse

  DOI：10.1021/jo980689e

  日期：1998.11.1

  The synthesis of the penta-N-protected polyamine homocaldopentamine PA 4333, 1, tert-butyl N-[9-allyl-16-azido-13-(2,2,2-trichloro-tert-butoxycarbonyl)-5-(trimethylsilylethylsulfonyl)-5,9,13-triazahexadec-1-yl]carbamate}, containing five independent amino-protecting groups is described. These five protecting groups used-allyl, azido, tert-butoxycarbonyl (BOC), 2,2,2-trichloro-tert-butoxycarbonyl (TCBOC), and trimethylsilylethylsulfonyl (SES)-were removed selectively. The acylation with p-methoxycinnamoyl chloride at each nitrogen of the pentaamine was determined.