3-chloro-5-morpholinobenzaldehyd | 1446818-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-chloro-5-morpholinobenzaldehyd
• 英文别名: 3-Chloro-5-morpholin-4-ylbenzaldehyde；3-chloro-5-morpholin-4-ylbenzaldehyde
• CAS: 1446818-81-0
• 化学式: C₁₁H₁₂ClNO₂
• 分子量: 225.675
• InChiKey: COYJZHDTABPION-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 3-溴-5-氯苯甲醛 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 甲苯 为溶剂， 以52%的产率得到3-chloro-5-morpholinobenzaldehyd
  参考文献：
  名称：

  [EN] PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
  [FR] COMPOSÉS DE PYRAZOLE, PROCÉDÉS DE PRODUCTION ET UTILISATION

  摘要：

  本文提供了吡唑化合物和包含这些化合物的药物组合物。这些化合物和组合物可用作MAGL和/或FAAH的调节剂。此外，这些化合物和组合物可用于治疗例如疼痛等疾病。

  公开号：

  WO2017087863A1

文献信息

• [EN] CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME<br/>[FR] COMPOSÉS DE CARBAMATE ET LEUR PRÉPARATION ET UTILISATION
  申请人：ABIDE THERAPEUTICS

  公开号：WO2013103973A1

  公开（公告）日：2013-07-11

  This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compunds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

  本公开提供了可能是MAGL和/或ABHD6的调节剂的化合物和组合物，以及它们作为药用剂的用途，它们的制备过程，以及包括所公开化合物作为至少一种活性剂的药物组合物。该公开还提供了一种治疗有需要的患者的方法，其中患者患有疼痛、实体肿瘤癌和/或肥胖等症状，包括给予公开的化合物或组合物。
• CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME
  申请人：Abide Therapeutics, Inc.

  公开号：US20150148330A1

  公开（公告）日：2015-05-28

  This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

  本公开提供了可能是MAGL和/或ABHD6调节剂的化合物和组合物，以及它们作为药物制剂的用途，其制备过程和包括所述化合物作为至少一种活性剂的药物组合物。本公开还提供了一种治疗患有疼痛、实体肿瘤癌和/或肥胖等症状的患者的方法，包括给予所述化合物或组合物。
• CARBAMATE COMPOUNDS FOR USE IN THERAPY
  申请人：Lundbeck La Jolla Research Center, Inc.

  公开号：EP3698782A1

  公开（公告）日：2020-08-26

  This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compunds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

  本公开提供了可作为MAGL和/或ABHD6调节剂的化合物和组合物及其作为药剂的用途、制备工艺，以及包括所公开的组合物作为至少一种活性剂的药物组合物。本公开还提供了治疗有需要的患者的方法，其中患者患有疼痛、实体瘤癌症和/或肥胖症等适应症，包括施用公开的化合物或组合物。
• Pyrazole compounds and methods of making and using same
  申请人：ABIDE THERAPEUTICS, INC.

  公开号：US10323038B2

  公开（公告）日：2019-06-18

  Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

  本文提供了吡唑化合物和包含所述化合物的药物组合物。所述化合物和组合物可用作 MAGL 和/或 FAAH 的调节剂。此外，所述化合物和组合物还可用于治疗疼痛等疾病。
• Carbamate compounds and methods of making and using same
  申请人：Lundbeck La Jolla Research Center, Inc.

  公开号：US11021453B2

  公开（公告）日：2021-06-01

  This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.

  本公开提供了可作为MAGL和/或ABHD6调节剂的化合物和组合物，以及它们作为药剂的用途、制备工艺和包括公开化合物作为至少一种活性剂的药物组合物。本公开还提供了一种治疗有需要的患者的方法，其中患者患有创伤后应激障碍，该方法包括施用所公开的化合物或组合物。