[2-[(R)-[tert-butyl(diphenyl)silyl]oxy-phenylmethyl]phenyl]methyl methanesulfonate | 244254-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-[(R)-[tert-butyl(diphenyl)silyl]oxy-phenylmethyl]phenyl]methyl methanesulfonate
• CAS: 244254-87-3
• 化学式: C₃₁H₃₄O₄SSi
• 分子量: 530.76
• InChiKey: GKVXASJUBOFYMF-SSEXGKCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [2-[(R)-[tert-butyl(diphenyl)silyl]oxy-phenylmethyl]phenyl]methyl methanesulfonate 在 lithium aluminium tetrahydride 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 (R)-o-methylbenzhydrol
  参考文献：
  名称：

  Enantioresolution by the chiral phthalic acid method: absolute configurations of (2-methylphenyl)phenylmethanol and related compounds

  摘要：

  Racemic (2-hydroxymethylphenyl)phenylmethanol 5 was enantioresolved by the chiral phthalic acid method using acid-amide 2, and the absolute configurations of (-)-(2-methylphenyl)phenylmethanol 3 and related o-substituted diphenylmethanol derivatives were unambiguously determined by X-ray crystallography and chemical correlation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00231-1
• 作为产物：
  描述：

  邻苯甲酰苯甲酸甲酯 在 咪唑 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 potassium carbonate 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 [2-[(R)-[tert-butyl(diphenyl)silyl]oxy-phenylmethyl]phenyl]methyl methanesulfonate
  参考文献：
  名称：

  Enantioresolution by the chiral phthalic acid method: absolute configurations of (2-methylphenyl)phenylmethanol and related compounds

  摘要：

  Racemic (2-hydroxymethylphenyl)phenylmethanol 5 was enantioresolved by the chiral phthalic acid method using acid-amide 2, and the absolute configurations of (-)-(2-methylphenyl)phenylmethanol 3 and related o-substituted diphenylmethanol derivatives were unambiguously determined by X-ray crystallography and chemical correlation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00231-1

文献信息

• Enantioresolution by the chiral phthalic acid method: absolute configurations of (2-methylphenyl)phenylmethanol and related compounds
  作者：Masataka Watanabe、Shunsuke Kuwahara、Nobuyuki Harada、Masatoshi Koizumi、Takeshi Ohkuma

  DOI：10.1016/s0957-4166(99)00231-1

  日期：1999.6

  Racemic (2-hydroxymethylphenyl)phenylmethanol 5 was enantioresolved by the chiral phthalic acid method using acid-amide 2, and the absolute configurations of (-)-(2-methylphenyl)phenylmethanol 3 and related o-substituted diphenylmethanol derivatives were unambiguously determined by X-ray crystallography and chemical correlation. (C) 1999 Elsevier Science Ltd. All rights reserved.