(3-(3-((undec-10-ynyloxy)carbonyl)-1H-pyrrol-1-yl)phenoxycarbonyl)(6-phenylhexyl)amine | 1392287-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (3-(3-((undec-10-ynyloxy)carbonyl)-1H-pyrrol-1-yl)phenoxycarbonyl)(6-phenylhexyl)amine
• 英文别名: Undec-10-ynyl 1-[3-(6-phenylhexylcarbamoyloxy)phenyl]pyrrole-3-carboxylate
• CAS: 1392287-65-8
• 化学式: C₃₅H₄₄N₂O₄
• 分子量: 556.745
• InChiKey: MHXWVPQIDPBFMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  41
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-苯基-1-己胺 在 碳酸氢钠 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 16.42h， 生成 (3-(3-((undec-10-ynyloxy)carbonyl)-1H-pyrrol-1-yl)phenoxycarbonyl)(6-phenylhexyl)amine
  参考文献：
  名称：

  Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases

  摘要：

  Fatty acid amide hydrolase (FAAH, EC 3.5.1.99) is the main enzyme catabolizing endocannabinoid fatty acid amides. FAAH inactivation promotes beneficial effects upon pain and anxiety without the side effects accompanying agonists of type-1 cannabinoid receptors. Aiming at discovering new selective FAAH inhibitors, we developed a series of compounds (5a-u) characterized by a functionalized heteroaromatic scaffold. Particularly, 5c and 5d were identified as extremely potent, noncompetitive, and reversible FAAH inhibitors endowed with a remarkable selectivity profile and lacking interaction with the hERG channels. In vivo antinociceptive activity was demonstrated for 5c, 5d, and 5n at a dose much lower than that able to induce either striatal and limbic stereotypies or anxiolytic activity, thus outlining their potential to turn into optimum preclinical candidates. Aiming at improving pharmacokinetic properties and metabolic stability of 5d, we developed a subset of nanomolar dialyzable FAAH inhibitors (5v-z), functionalized by specific polyethereal lateral chains and fluorinated aromatic rings.

  DOI：

  10.1021/jm300689c

文献信息

• Discovery of Potent Inhibitors of Human and Mouse Fatty Acid Amide Hydrolases
  作者：Stefania Butini、Margherita Brindisi、Sandra Gemma、Patrizia Minetti、Walter Cabri、Grazia Gallo、Silvia Vincenti、Emanuela Talamonti、Franco Borsini、Antonio Caprioli、Maria Antonietta Stasi、Stefano Di Serio、Sindu Ros、Giuseppe Borrelli、Samuele Maramai、Filomena Fezza、Giuseppe Campiani、Mauro Maccarrone

  DOI：10.1021/jm300689c

  日期：2012.8.9

  Fatty acid amide hydrolase (FAAH, EC 3.5.1.99) is the main enzyme catabolizing endocannabinoid fatty acid amides. FAAH inactivation promotes beneficial effects upon pain and anxiety without the side effects accompanying agonists of type-1 cannabinoid receptors. Aiming at discovering new selective FAAH inhibitors, we developed a series of compounds (5a-u) characterized by a functionalized heteroaromatic scaffold. Particularly, 5c and 5d were identified as extremely potent, noncompetitive, and reversible FAAH inhibitors endowed with a remarkable selectivity profile and lacking interaction with the hERG channels. In vivo antinociceptive activity was demonstrated for 5c, 5d, and 5n at a dose much lower than that able to induce either striatal and limbic stereotypies or anxiolytic activity, thus outlining their potential to turn into optimum preclinical candidates. Aiming at improving pharmacokinetic properties and metabolic stability of 5d, we developed a subset of nanomolar dialyzable FAAH inhibitors (5v-z), functionalized by specific polyethereal lateral chains and fluorinated aromatic rings.