methyl (14E)-14-ethylidene-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl (14E)-14-ethylidene-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate
• 化学式: C₂₀H₂₂N₂O₃
• 分子量: 338.4
• InChiKey: BDXYPHKGNUGUFG-JYOAFUTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASES
  申请人：Kunming Institute Of Botany, The Chinese Academy Of Sciences

  公开号：EP3375443A1

  公开（公告）日：2018-09-19

  The invention provides a pharmaceutical composition for treating a respiratory disease, wherein the pharmaceutical composition comprises one or more components selected frompicrinine, vallesamine, scholaricine, and 19-epischolaricine. The pharmaceutical composition has a good protective effect on the respiratory system, and can be used in treatment of a relevant disease.

  本发明提供了一种用于治疗呼吸系统疾病的药物组合物，其中该药物组合物包含一种或多种选自皮克宁、瓦利萨明、学者碱和 19-表学者碱的成分。该药物组合物对呼吸系统具有良好的保护作用，可用于治疗相关疾病。
• Pharmaceutical composition for treating respiratory disease
  申请人：Kunming Institute of Botany, The Chinese Academy of Sciences

  公开号：US10603345B2

  公开（公告）日：2020-03-31

  The invention provides a pharmaceutical composition for treating a respiratory disease, wherein the pharmaceutical composition comprises one or more components selected from picrinine, vallesamine, scholaricine, and 19-epischolaricine. The pharmaceutical composition has a good protective effect on the respiratory system, and can be used in treatment of a relevant disease.

  本发明提供了一种用于治疗呼吸系统疾病的药物组合物，其中该药物组合物包含一种或多种选自皮克宁、瓦勒沙明、学者碱和 19-表异构体碱的成分。该药物组合物对呼吸系统具有良好的保护作用，可用于治疗相关疾病。
• PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASE
  申请人：Kunming Institute of Botany, The Chinese Academy of Sciences

  公开号：US20180344792A1

  公开（公告）日：2018-12-06

  The invention provides a pharmaceutical composition for treating a respiratory disease, wherein the pharmaceutical composition comprises one or more components selected from picrinine, vallesamine, scholaricine, and 19-epischolaricine. The pharmaceutical composition has a good protective effect on the respiratory system, and can be used in treatment of a relevant disease.
• [EN] METHOD FOR THE BIOCATALYTIC ALKYLATION OF A SUBSTRATE<br/>[FR] PROCÉDÉ POUR L'ALKYLATION BIOCATALYTIQUE D'UN SUBSTRAT
  申请人：UNIV BASEL

  公开号：WO2020053196A1

  公开（公告）日：2020-03-19

  The present invention relates to a method for alkylating a substrate comprising an alkylation step a) wherein a S-alkyltransferase transfers an alkyl group from an alkyl donor to a sulfur- or selenium-containing carrier compound, yielding an alkylated carrier compound and an alkylation step b) wherein a N-, C-, O-, S- or P- alkyltransferase transfers the alkyl group from the alkylated carrier compound to the substrate, yielding an alkylated substrate and a dealkylated carrier compound, and wherein at least a part of the dealkylated carrier compound is recycled to regenerate the alkylated carrier compound. Furthermore, the invention relates to a method for producing the alkylated sulfur- or selenium-containing carrier compound. The invention also relates to kits for alkylating a substrate or for producing the alkylated carrier compound and the use of the components and kits for the production of an alkylated substrate or an alkylated carrier compound.