2-{[3-Chloro-4-(trifluoromethoxy)phenyl]methylidene}propanedinitrile | 771564-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-{[3-Chloro-4-(trifluoromethoxy)phenyl]methylidene}propanedinitrile
• 英文别名: 2-[[3-chloro-4-(trifluoromethoxy)phenyl]methylidene]propanedinitrile
• CAS: 771564-45-5
• 化学式: C₁₁H₄ClF₃N₂O
• 分子量: 272.614
• InChiKey: UKZFLJUDCWZZEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  56.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-chloro-5-((2-(2-(furan-2-yl)-1-nitrovinyl)-4,5-dihydro-1H-imidazol-1-yl)methyl)pyridine 、 2-{[3-Chloro-4-(trifluoromethoxy)phenyl]methylidene}propanedinitrile 以 乙酸乙酯 为溶剂， 生成 1-[(6-Chloropyridin-3-yl)methyl]-5-[3-chloro-4-(trifluoromethoxy)phenyl]-7-(furan-2-yl)-8-nitro-2,3,5,7-tetrahydroimidazo[1,2-a]pyridine-6,6-dicarbonitrile
  参考文献：
  名称：

  Designing Tetrahydroimidazo[1,2-a]pyridine Derivatives via Catalyst-free Aza-Diels−Alder Reaction (ADAR) and Their Insecticidal Evaluation

  摘要：

  A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target compounds were tested against pea aphids (Aphis craccivora), which showed that activities were strongly influenced by the substituents and their positions. Especially, the introduction of a fluoro group at the 2- position increased activities.

  DOI：

  10.1021/jf100645y
• 作为产物：
  描述：

  3-氯-4-三氟甲氧基苯甲醛 、 丙二腈 在 哌啶 作用下， 以 乙醇 为溶剂， 生成 2-{[3-Chloro-4-(trifluoromethoxy)phenyl]methylidene}propanedinitrile
  参考文献：
  名称：

  Designing Tetrahydroimidazo[1,2-a]pyridine Derivatives via Catalyst-free Aza-Diels−Alder Reaction (ADAR) and Their Insecticidal Evaluation

  摘要：

  A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target compounds were tested against pea aphids (Aphis craccivora), which showed that activities were strongly influenced by the substituents and their positions. Especially, the introduction of a fluoro group at the 2- position increased activities.

  DOI：

  10.1021/jf100645y

文献信息

• [DE] SUBSTITUIERTE 2 -AMINO - 3 - CYANOPYRIDINE ALS INHIBITOREN DES NATRIUM CALCIUM AUSTAUSCHES UND IHRE VERWENDUNG BEI KARDIOVASKULÄREN ERKRANKUNGEN<br/>[EN] SUBSTITUTED 2-AMINO-3-CYANOPYRIDINES AS INHIBITORS OF SODIUM-CALCIUM EXCHANGE AND USE THEREOF FOR CARDIOVASCULAR DISEASES<br/>[FR] 2-AMINO-3-CYANOPYRIDINES SUBSTITUÉES UTILISÉES COMME INHIBITEURS DE L'ÉCHANGE SODIUM-CALCIUM ET LEURS UTILISATIONS DANS LE CAS DE MALADIES CARDIOVASCULAIRES
  申请人：BAYER IP GMBH

  公开号：WO2013144191A1

  公开（公告）日：2013-10-03

  Die vorliegende Anmeldung betrifft neue substituierte 2-Amino-3-cyanopyridine, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention kardiovaskulärer Erkrankungen.
• Designing Tetrahydroimidazo[1,2-<i>a</i>]pyridine Derivatives via Catalyst-free Aza-Diels−Alder Reaction (ADAR) and Their Insecticidal Evaluation
  作者：Wenwen Zhang、Yinbo Chen、Weidong Chen、Zewen Liu、Zhong Li

  DOI：10.1021/jf100645y

  日期：2010.5.26

  A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target compounds were tested against pea aphids (Aphis craccivora), which showed that activities were strongly influenced by the substituents and their positions. Especially, the introduction of a fluoro group at the 2- position increased activities.