2-Methyl-1-propan-2-yl-4,5,6,7-tetrahydroindole | 93698-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Methyl-1-propan-2-yl-4,5,6,7-tetrahydroindole
• CAS: 93698-80-7
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: LUKUFKZARQBFIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  N-(cyclohexylidene)isopropylamine 以 乙腈 为溶剂， 反应 15.0h， 生成 2-Methyl-1-propan-2-yl-4,5,6,7-tetrahydroindole
  参考文献：
  名称：

  Pyrrol-Anellierung von Ketonen durch Addition deprotonierter Imine an 2,-(N-Methylanilino)-acrylonitrile

  摘要：

  DOI：

  10.1055/s-1984-30914

文献信息

• AHLBRECHT, H.;DAACKE, A. VON, SYNTHESIS, BRD, 1984, N 7, 610-614
  作者：AHLBRECHT, H.、DAACKE, A. VON

  DOI：——

  日期：——
• NOVEL COMPOUNDS
  申请人：INFLAZOME LIMITED

  公开号：US20200399242A1

  公开（公告）日：2020-12-24

  The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 may optionally be substituted; R2 is an α,α′-substituted cyclic group which may optionally be further substituted; R3 and R4 are each independently hydrogen, halogen, —OH, —NH 2 , —CN, —R 5 , —OR 5 , —NHRs or —N(R 5 )2; or R 3 and R 4 together with the carbon atom to which they are attached may form a 3- to 7-membered saturated or unsaturated, optionally substituted cyclic group; and R5 is independently optionally substituted C 1 -C 4 alkyl. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP 3 .
• Pyrrol-Anellierung von Ketonen durch Addition deprotonierter Imine an 2,-(<i>N</i>-Methylanilino)-acrylonitrile
  作者：Hubertus Ahlbrecht、Axel Von Daacke

  DOI：10.1055/s-1984-30914

  日期：——