ethyl (2,6-dimethoxy-4-nitrophenoxy)acetate | 957420-26-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2,6-dimethoxy-4-nitrophenoxy)acetate
• 英文别名: ethyl 2-(2,6-dimethoxy-4-nitrophenoxy)acetate
• CAS: 957420-26-7
• 化学式: C₁₂H₁₅NO₇
• 分子量: 285.254
• InChiKey: JCPNNIYHVIXVLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  ethyl (2,6-dimethoxy-4-nitrophenoxy)acetate 在 lithium hydroxide 、 水 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 cyclopentyl N-[(2,6-dimethoxy-4-nitrophenoxy)acetyl]-L-leucinate
  参考文献：
  名称：

  WO2007/132146

  摘要：

  公开号：
• 作为产物：
  描述：

  2,6-二甲氧基苯酚 在 硝酸 、 potassium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 ethyl (2,6-dimethoxy-4-nitrophenoxy)acetate
  参考文献：
  名称：

  [EN] KINASE INHIBITORS
  [FR] INHIBITEURS DE KINASES

  摘要：

  公开号：

  WO2011060295A8

文献信息

• DHFR Enzyme Inhibitors
  申请人：Davidson Alan Hornsby

  公开号：US20090118311A1

  公开（公告）日：2009-05-07

  Compounds of formula (I) or (II) are dihydrofolate reductase inhibitors, useful for the treatment of, for example, cell proliferative diseases: wherein A and D are independently —CHR 7 — or —NR 7 —; E and G are independently ═CR 7 — or ═N—; each R 6 independently represents hydrogen or —OR 7 ; R 7 is hydrogen or C 1 -C 6 alkyl; R 1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R 2 is the side chain of a natural or non-natural alpha amino acid which does not contain a carboxyl, or carboxyl ester group; Y is a bond, —C(═O)—, —S(═O) 2 —, —C(═O)NR 3 —, —C(═S)—NR 3 , —C(═NH)NR 3 or —S(═O) 2 NR 3 — wherein R 3 is hydrogen or optionally substituted C 1 -C 6 alkyl; L 1 is a divalent radical of formula -(Alk 1 ) m (Q) n (Alk 2 ) p - wherein m, n and p are independently 0 or 1, and Q, Alk 1 and Alk 2 are as defined in the claims; X 1 represents a bond; —C(═O); or —S(═O) 2 —; —NR 4 C(═O)—, —C(═O)NR 4 —, —NR 4 C(═O)NR 5 —, —NR 4 S(═O) 2 —, or —S(═O) 2 NR 4 — wherein R 4 and R 5 are independently hydrogen or optionally substituted C 1 -C 6 alkyl; and z is 0 or 1.

  式(I)或(II)的化合物是二氢叶酸还原酶抑制剂，适用于治疗细胞增殖性疾病，其中A和D独立地为—CHR7—或—NR7—;E和G独立地为═CR7—或═N—;每个R6独立地表示氢或—OR7;R7是氢或C1-C6烷基;R1是羧酸基(—COOH)，或者是可由一个或多个细胞内羧酸酯酶水解为羧酸基的酯基;R2是天然或非天然α氨基酸的侧链，不含羧基或羧酯基;Y是键，—C(═O)—、—S(═O)2—、—C(═O)NR3—、—C(═S)—NR3、—C(═NH)NR3或—S(═O)2NR3—其中R3是氢或可选取代的C1-C6烷基;L1是式-(Alk1)m(Q)n(Alk2)p-的二价基团，其中m、n和p独立地为0或1，而Q、Alk1和Alk2如权利要求所定义;X1表示键;—C(═O);或—S(═O)2—;—NR4C(═O)—、—C(═O)NR4—、—NR4C(═O)NR5—、—NR4S(═O)2—或—S(═O)2NR4—其中R4和R5独立地为氢或可选取代的C1-C6烷基;z为0或1。
• Kinase Inhibitors
  申请人：Lee Jaekyoo

  公开号：US20110281841A1

  公开（公告）日：2011-11-17

  The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

  本发明提供了一种新的蛋白激酶抑制剂群，包括吡咯嘧啶和吡唑嘧啶衍生物，以及其药学上可接受的盐和前药，用于治疗细胞增殖性疾病和疾病，例如癌症、自身免疫性疾病、感染、心血管疾病和神经退行性疾病。本发明提供了合成和给药蛋白激酶抑制剂化合物的方法。本发明还提供了包含至少一种蛋白激酶抑制剂化合物和药学上可接受的载体、稀释剂或赋形剂的制剂。本发明还提供了在合成吡咯嘧啶和吡唑嘧啶衍生物的过程中产生的有用中间体。
• DHFR enzyme inhibitors
  申请人：Chroma Therapeutics Ltd.

  公开号：US08211900B2

  公开（公告）日：2012-07-03

  Compounds of formula (I) or (II) are dihydrofolate reductase inhibitors, useful for the treatment of, for example, cell proliferative diseases: wherein A and D are independently —CHR7— or —NR7—; E and G are independently ═CR7— or ═N—; each R6 independently represents hydrogen or —OR7; R7 is hydrogen or C1-C6 alkyl; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid which does not contain a carboxyl, or carboxyl ester group; Y is a bond, —C(═O)—, —S(═O)2—, —C(═O)NR3—, —C(═S)—NR3, —C(═NH)NR3 or —S(═O)2NR3— wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n and p are independently 0 or 1, and Q, Alk1 and Alk2 are as defined in the claims; X1 represents a bond; —C(═O); or —S(═O)2—; —NR4C(═O)—, —C(═O)NR4—, —NR4C(═O)NR5—, —NR4S(═O)2—, or —S(═O)2NR4— wherein R4 and R5 are independently hydrogen or optionally substituted C1-C6 alkyl; and z is 0 or 1.

  式(I)或(II)的化合物是二氢叶酸还原酶抑制剂，可用于治疗细胞增殖性疾病，其中A和D独立地为-CHR7-或-NR7-; E和G独立地为═CR7-或═N-; 每个R6独立地表示氢或-OR7; R7为氢或C1-C6烷基; R1为羧酸基(—COOH)或可由一个或多个细胞内羧酸酯酶水解为羧酸基的酯基; R2为天然或非天然α氨基酸的侧链，不含羧基或羧酯基; Y为键，-C(═O)-，-S(═O)2-，-C(═O)NR3-，-C(═S)-NR3，-C(═NH)NR3或-S(═O)2NR3-，其中R3为氢或可选取代的C1-C6烷基; L1为式-(Alk1)m(Q)n(Alk2)p-的二价基团，其中m、n和p独立地为0或1，Q、Alk1和Alk2如权利要求所定义; X1表示键，-C(═O); 或-S(═O)2-; -NR4C(═O)-，-C(═O)NR4-，-NR4C(═O)NR5-，-NR4S(═O)2-或-S(═O)2NR4-，其中R4和R5独立地为氢或可选取代的C1-C6烷基; z为0或1。
• Kinase inhibitors
  申请人：Lee Jaekyoo

  公开号：US08629132B2

  公开（公告）日：2014-01-14

  The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.

  本发明提供了一种新的蛋白激酶抑制剂群，即吡啶并嘧啶和吡唑并嘧啶衍生物，以及其药学上可接受的盐和前药，这些化合物可用于治疗细胞增殖性疾病和疾病，如癌症、自身免疫性疾病、感染、心血管疾病和神经退行性疾病。本发明提供了合成和给药蛋白激酶抑制剂化合物的方法。本发明还提供了包含至少一种蛋白激酶抑制剂化合物和药学上可接受的载体、稀释剂或辅料的制剂。本发明还提供了在合成吡啶并嘧啶和吡唑并嘧啶衍生物过程中产生的有用中间体。
• KINASE INHIBITORS
  申请人：Genosco

  公开号：EP2498607B1

  公开（公告）日：2016-02-17