5-氯-2-羟基-4-甲基-苯甲酸 | 35458-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-氯-2-羟基-4-甲基-苯甲酸
• 英文名称: 5-Chlor-2-hydroxy-4-methyl-benzoesaeure
• 英文别名: 5-Chloro-2-hydroxy-4-methylbenzoic acid
• CAS: 35458-35-6
• 化学式: C₈H₇ClO₃
• mdl: MFCD06203575
• 分子量: 186.595
• InChiKey: PNBKMRRXXVGPTJ-UHFFFAOYSA-N

物化性质

• 熔点：
  205 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• 沸点：
  342.4±42.0 °C(Predicted)
• 密度：
  1.450±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-氯-2-羟基-4-甲基-苯甲酸 在 氯化亚砜 作用下， 生成 5-chloro-2-hydroxy-4-methyl-benzoyl chloride
  参考文献：
  名称：

  v. Walther; Zipper, Journal fur praktische Chemie (Leipzig 1954), 1915, vol. <2> 91, p. 388

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-3-甲基苯酚 生成 5-氯-2-羟基-4-甲基-苯甲酸
  参考文献：
  名称：

  v. Walther; Zipper, Journal fur praktische Chemie (Leipzig 1954), 1915, vol. <2> 91, p. 380

  摘要：

  DOI：

文献信息

• Total synthesis of halogenated spirocyclic polyketide (±)-actinospirol A
  作者：Yuichiro Kawamoto、Toyoharu Kobayashi、Hisanaka Ito

  DOI：10.1016/j.tetlet.2022.153975

  日期：2022.8

  The first total synthesis of racemic actinospirol A was accomplished. The synthetic features include Sonogashira coupling to connect two aromatic parts, oxidation to a diketone, and acid-mediated spirocyclization. The present strategy would be applicable to synthesize multi-substituted benzofuranones and isobenzofuranones to form fused spirocyclic structure.

  完成了外消旋放线螺菌素A的首次全合成。合成特征包括连接两个芳香部分的 Sonogashira 偶联、氧化成二酮和酸介导的螺环化。本策略适用于合成多取代苯并呋喃酮和异苯并呋喃酮以形成稠合螺环结构。
• A case controlled study of laparoscopic incisional hernia repair
  作者：R. Chari、V. Chari、M. Eisenstat、R. Chung

  DOI：10.1007/s004649900079

  日期：2000.2

  Background: Although the feasibility of laparoscopic incisional herniorrhaphy has been demonstrated, its advantages over the open technique are still unproven,Methods: Fourteen consecutive laparoscopic incisional hernia repairs were compared with 14 matched controls of the open repair done by the same surgeon at the same institution. The controls were selected by a medical record technician not connected with the study, The cases were selected to match diagnoses, ASA status, and body weight as closely as possible. The outcome data for operating time, blood loss, hospitalization, resumption of oral intake, and postoperative complications were analyzed for statistically significant differences.Results: There was no statistical difference between the two groups in the parameters of blood loss, hospital days, or days to oral intake, The laparoscopic operation took 40% longer. Similar complications were seen in both groups. No mortality or early recurrences occurred in either group.Conclusion: Laparoscopic incisional hernia repair of at least moderate complexity had no demonstrable advantage over the open repair in the present study.
• Gattermann, Chemische Berichte, 1893, vol. 26, p. 1847
  作者：Gattermann

  DOI：——

  日期：——
• Wittig, Justus Liebigs Annalen der Chemie, 1926, vol. 446, p. 179
  作者：Wittig

  DOI：——

  日期：——
• Wittig, Chemische Berichte, 1924, vol. 57, p. 92
  作者：Wittig

  DOI：——

  日期：——